Planar cell polarity signaling in craniofacial development

Jacek Topczewski*, Rodney M. Dale, Barbara E. Sisson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalOrganogenesis
Volume7
Issue number4
DOIs
StatePublished - Oct 2011

Keywords

  • Cranial neural crest
  • Craniofacial development
  • Glypicans
  • Planar cell polarity
  • Skull formation
  • Wnt pathways

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology
  • Developmental Biology
  • Transplantation

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