Planar cell polarity signaling in craniofacial development

Jacek Topczewski*, Rodney M. Dale, Barbara E. Sisson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
Issue number4
StatePublished - Oct 2011


  • Cranial neural crest
  • Craniofacial development
  • Glypicans
  • Planar cell polarity
  • Skull formation
  • Wnt pathways

ASJC Scopus subject areas

  • Transplantation
  • Biomedical Engineering
  • Embryology
  • Developmental Biology


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