Abstract
Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 255-259 |
| Number of pages | 5 |
| Journal | Organogenesis |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2011 |
Funding
This work was supported by the National Institutes of Health— NIDCR Grants R01DE016678 (J.T.), F32DE019058 (B.E.S.), and F32DE019986 (R.M.D.).
Keywords
- Cranial neural crest
- Craniofacial development
- Glypicans
- Planar cell polarity
- Skull formation
- Wnt pathways
ASJC Scopus subject areas
- Transplantation
- Biomedical Engineering
- Embryology
- Developmental Biology