Plasma and dialysate immunoglobulin g in continuous ambulatory peritoneal dialysis patients: A multicenter study

Amedeo F. De Vecchi*, Joel D. Kopple, Gerald A. Young, Karl D. Nolph, Edward F. Vonesh, Claudia Castelnovo, Janet Dichiro, Allen Nissenson, Alek M. Brownjohn, Barbara Prowant, Corrine Algrim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Peritoneal dialysate immunoglobin (Ig)G concentrations were measured in 120 continuous ambulatory peritoneal diaysis (CAPD) patients evaluated at four dialysis centers in different countries to assess the normal range for dialysate IgG and to investigate the relationships of this protein levels with peritoneal episodes. For 65 of these patients, plasma IgG levels were determined, and IgG clearances were calculated. The mean dialysate concentration of IgG was 6.9 ± 4.2 mg/dl, and there was no difference between men and women or between patients who had or had not previously undergone hemodialysis. Dialysate IgG concentrations were significantly related to residual renal creatinine clearance and negatively correlated with dialysate volume, plasma albumin and total protein. There were no significant correlations between IgG levels in the dialysate and age, protein losses in the dialysate, time on CAPD or time from the last peritonitis episode. Plasma and dialysate IgG were unrelated to the incidence of peritonitis, statistical analysis being performed with different methods. These results suggest that IgG levels in the dialysate or plasma are not a major factor in the prevention of CAPD peritonitis.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalAmerican Journal of Nephrology
Volume10
Issue number6
DOIs
StatePublished - 1990

Keywords

  • Immunoglobulin G
  • Peritoneal defense mechanisms
  • Peritonitis prevention

ASJC Scopus subject areas

  • Nephrology

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