Plasma C peptide and diagnosis of factitious hyperinsulinism. Study of an insulin dependent diabetic patient with 'spontaneous' hypoglycemia

C. Couropmitree, N. Freinkel, T. C. Nagel, D. L. Horwitz, A. H. Rubenstein, B. Metzger, A. H. Rubenstein, R. Hahnel

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Factitious hyperinsulinism was suspected in a patient with an 11 yr history of insulin dependent, ketosis prone diabetes mellitus who began to experience repetitive episodes of 'spontaneous' hypoglycemia. Insulin mediation of the hypoglycemia was confirmed by documenting that urinary insulin and total extractable insulin in plasma increased during periods of hypoglycemia. Failure to detect significant amounts of human C peptide by radioimmunoassay during periods of hypoglycemia or in response to stimulation with glucagon, leucine, or tolbutamide indicated that the insulin was not endogenous. The diagnosis of factitious hyperinsulinism was ultimately proved by the finding of radioactivity in the patient's urine after 131I Hippuran was added to a vial of insulin found in the patient's room.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalUnknown Journal
Volume82
Issue number2
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Internal Medicine

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