Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure

Bernd Hoppe, Markus J. Kemper, Arend Bökenkamp, Anthony A. Portale, Richard A. Cohn, Craig B. Langman*

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Plasma calcium oxalate supersaturation in children with primary' hyperoxaluria and end-stage renal failure. Background. Children with primary hyperoxaluria type 1 (PH 1) are at great risk to develop systemic oxalosis in endstage renal disease (ESRD), as endogenous oxalate production exceeds oxalate removal by dialytic therapy. As oxalate accumulates, calcium oxalate (CaOx) tissue deposition occurs. Children with other causes of ESRD, however, are not prone to CaOx deposition despite elevated plasma oxalate (P(ox)) levels. Methods. Our study objective was to examine the potential mechanisms for these observations. We measured P(ox), sulfate, citrate, and calculated CaOx saturation (β(Ca,Ox)) in 7 children with ESRD caused by PH 1 and in 33 children with nonPH-related ESRD. Maintenance hemodialysis (HD) was performed in 6 PH 1 and 22 non-PH patients: Pre- and post-HD levels were analyzed at this point and were repeated twice within 12 months in 5 PH1 and 14 non-PH patients. Samples were obtained only once in 12 patients (one PH 1) on peritoneal dialysis (PD). After liver-kidney or kidney transplantation, plasma levels were measured repetitively. Results. The mean P(Ox) was higher in PH 1 (125.7 ± 17.9 μol/liter) than in non-PH patients (44.2 ± 3.3 μol/liter, P < 10-4). All other determined anions did not differ between the two groups, β(CaOx) was higher in PH 1 (4.71 ± 0.69 relative units) compared with non-PH children (1.56 ± 0.12 units, P < 10-4). P(Ox) and β(CaOx) were correlated in both the PH 1 (r = 0.98, P < 2 X 10-4) and the non-PH group (r = 0.98, P < 10-4). P(Ox) and β(CaOx) remained stable over time in the non-PH children, whereas an insignificant decline was observed in PHI patients after six months of more aggressive dialysis, β(CaOx) was supersaturated (more than 1) in all PH 1 and in 25 out of 33 non-PH patients. Post-HD β(CaOx) remained more than 1 in all PH 1, but in only 2 out of 22 non-PH patients. In non-PH children, P(Ox) and β(CaOx) decreased to normal within three weeks after successful kidney transplantation, whereas the levels still remained elevated seven months after combined liver-kidney transplantation in two PH 1 patients. Conclusion. Systemic oxalosis in PH 1 children with ESRD is due to higher P(Ox) and β(CaOx) levels. As β(CaOx) remained supersaturated in PH 1 even after aggressive HD, oxalate accumulation increases, and CaOx tissue deposition occurs. Therefore, sufficient reduction of P(Ox) and β(CaOx) is crucial in PH 1 and might only be achieved by early, preemptive, combined liver-kidney transplantation or liver transplantation alone.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalKidney international
Volume56
Issue number1
DOIs
StatePublished - Jan 1 1999

Fingerprint

Primary Hyperoxaluria
Calcium Oxalate
Chronic Kidney Failure
Oxalates
Kidney
Kidney Transplantation
Renal Dialysis
Liver Transplantation
Hyperoxaluria
Primary hyperoxaluria type 1
Peritoneal Dialysis

Keywords

  • Crystal deposition
  • Liver
  • Oxalosis
  • Renal replacement therapy
  • Solid organ transplantation

ASJC Scopus subject areas

  • Nephrology

Cite this

Hoppe, Bernd ; Kemper, Markus J. ; Bökenkamp, Arend ; Portale, Anthony A. ; Cohn, Richard A. ; Langman, Craig B. / Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure. In: Kidney international. 1999 ; Vol. 56, No. 1. pp. 268-274.
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abstract = "Plasma calcium oxalate supersaturation in children with primary' hyperoxaluria and end-stage renal failure. Background. Children with primary hyperoxaluria type 1 (PH 1) are at great risk to develop systemic oxalosis in endstage renal disease (ESRD), as endogenous oxalate production exceeds oxalate removal by dialytic therapy. As oxalate accumulates, calcium oxalate (CaOx) tissue deposition occurs. Children with other causes of ESRD, however, are not prone to CaOx deposition despite elevated plasma oxalate (P(ox)) levels. Methods. Our study objective was to examine the potential mechanisms for these observations. We measured P(ox), sulfate, citrate, and calculated CaOx saturation (β(Ca,Ox)) in 7 children with ESRD caused by PH 1 and in 33 children with nonPH-related ESRD. Maintenance hemodialysis (HD) was performed in 6 PH 1 and 22 non-PH patients: Pre- and post-HD levels were analyzed at this point and were repeated twice within 12 months in 5 PH1 and 14 non-PH patients. Samples were obtained only once in 12 patients (one PH 1) on peritoneal dialysis (PD). After liver-kidney or kidney transplantation, plasma levels were measured repetitively. Results. The mean P(Ox) was higher in PH 1 (125.7 ± 17.9 μol/liter) than in non-PH patients (44.2 ± 3.3 μol/liter, P < 10-4). All other determined anions did not differ between the two groups, β(CaOx) was higher in PH 1 (4.71 ± 0.69 relative units) compared with non-PH children (1.56 ± 0.12 units, P < 10-4). P(Ox) and β(CaOx) were correlated in both the PH 1 (r = 0.98, P < 2 X 10-4) and the non-PH group (r = 0.98, P < 10-4). P(Ox) and β(CaOx) remained stable over time in the non-PH children, whereas an insignificant decline was observed in PHI patients after six months of more aggressive dialysis, β(CaOx) was supersaturated (more than 1) in all PH 1 and in 25 out of 33 non-PH patients. Post-HD β(CaOx) remained more than 1 in all PH 1, but in only 2 out of 22 non-PH patients. In non-PH children, P(Ox) and β(CaOx) decreased to normal within three weeks after successful kidney transplantation, whereas the levels still remained elevated seven months after combined liver-kidney transplantation in two PH 1 patients. Conclusion. Systemic oxalosis in PH 1 children with ESRD is due to higher P(Ox) and β(CaOx) levels. As β(CaOx) remained supersaturated in PH 1 even after aggressive HD, oxalate accumulation increases, and CaOx tissue deposition occurs. Therefore, sufficient reduction of P(Ox) and β(CaOx) is crucial in PH 1 and might only be achieved by early, preemptive, combined liver-kidney transplantation or liver transplantation alone.",
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Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure. / Hoppe, Bernd; Kemper, Markus J.; Bökenkamp, Arend; Portale, Anthony A.; Cohn, Richard A.; Langman, Craig B.

In: Kidney international, Vol. 56, No. 1, 01.01.1999, p. 268-274.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure

AU - Hoppe, Bernd

AU - Kemper, Markus J.

AU - Bökenkamp, Arend

AU - Portale, Anthony A.

AU - Cohn, Richard A.

AU - Langman, Craig B.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Plasma calcium oxalate supersaturation in children with primary' hyperoxaluria and end-stage renal failure. Background. Children with primary hyperoxaluria type 1 (PH 1) are at great risk to develop systemic oxalosis in endstage renal disease (ESRD), as endogenous oxalate production exceeds oxalate removal by dialytic therapy. As oxalate accumulates, calcium oxalate (CaOx) tissue deposition occurs. Children with other causes of ESRD, however, are not prone to CaOx deposition despite elevated plasma oxalate (P(ox)) levels. Methods. Our study objective was to examine the potential mechanisms for these observations. We measured P(ox), sulfate, citrate, and calculated CaOx saturation (β(Ca,Ox)) in 7 children with ESRD caused by PH 1 and in 33 children with nonPH-related ESRD. Maintenance hemodialysis (HD) was performed in 6 PH 1 and 22 non-PH patients: Pre- and post-HD levels were analyzed at this point and were repeated twice within 12 months in 5 PH1 and 14 non-PH patients. Samples were obtained only once in 12 patients (one PH 1) on peritoneal dialysis (PD). After liver-kidney or kidney transplantation, plasma levels were measured repetitively. Results. The mean P(Ox) was higher in PH 1 (125.7 ± 17.9 μol/liter) than in non-PH patients (44.2 ± 3.3 μol/liter, P < 10-4). All other determined anions did not differ between the two groups, β(CaOx) was higher in PH 1 (4.71 ± 0.69 relative units) compared with non-PH children (1.56 ± 0.12 units, P < 10-4). P(Ox) and β(CaOx) were correlated in both the PH 1 (r = 0.98, P < 2 X 10-4) and the non-PH group (r = 0.98, P < 10-4). P(Ox) and β(CaOx) remained stable over time in the non-PH children, whereas an insignificant decline was observed in PHI patients after six months of more aggressive dialysis, β(CaOx) was supersaturated (more than 1) in all PH 1 and in 25 out of 33 non-PH patients. Post-HD β(CaOx) remained more than 1 in all PH 1, but in only 2 out of 22 non-PH patients. In non-PH children, P(Ox) and β(CaOx) decreased to normal within three weeks after successful kidney transplantation, whereas the levels still remained elevated seven months after combined liver-kidney transplantation in two PH 1 patients. Conclusion. Systemic oxalosis in PH 1 children with ESRD is due to higher P(Ox) and β(CaOx) levels. As β(CaOx) remained supersaturated in PH 1 even after aggressive HD, oxalate accumulation increases, and CaOx tissue deposition occurs. Therefore, sufficient reduction of P(Ox) and β(CaOx) is crucial in PH 1 and might only be achieved by early, preemptive, combined liver-kidney transplantation or liver transplantation alone.

AB - Plasma calcium oxalate supersaturation in children with primary' hyperoxaluria and end-stage renal failure. Background. Children with primary hyperoxaluria type 1 (PH 1) are at great risk to develop systemic oxalosis in endstage renal disease (ESRD), as endogenous oxalate production exceeds oxalate removal by dialytic therapy. As oxalate accumulates, calcium oxalate (CaOx) tissue deposition occurs. Children with other causes of ESRD, however, are not prone to CaOx deposition despite elevated plasma oxalate (P(ox)) levels. Methods. Our study objective was to examine the potential mechanisms for these observations. We measured P(ox), sulfate, citrate, and calculated CaOx saturation (β(Ca,Ox)) in 7 children with ESRD caused by PH 1 and in 33 children with nonPH-related ESRD. Maintenance hemodialysis (HD) was performed in 6 PH 1 and 22 non-PH patients: Pre- and post-HD levels were analyzed at this point and were repeated twice within 12 months in 5 PH1 and 14 non-PH patients. Samples were obtained only once in 12 patients (one PH 1) on peritoneal dialysis (PD). After liver-kidney or kidney transplantation, plasma levels were measured repetitively. Results. The mean P(Ox) was higher in PH 1 (125.7 ± 17.9 μol/liter) than in non-PH patients (44.2 ± 3.3 μol/liter, P < 10-4). All other determined anions did not differ between the two groups, β(CaOx) was higher in PH 1 (4.71 ± 0.69 relative units) compared with non-PH children (1.56 ± 0.12 units, P < 10-4). P(Ox) and β(CaOx) were correlated in both the PH 1 (r = 0.98, P < 2 X 10-4) and the non-PH group (r = 0.98, P < 10-4). P(Ox) and β(CaOx) remained stable over time in the non-PH children, whereas an insignificant decline was observed in PHI patients after six months of more aggressive dialysis, β(CaOx) was supersaturated (more than 1) in all PH 1 and in 25 out of 33 non-PH patients. Post-HD β(CaOx) remained more than 1 in all PH 1, but in only 2 out of 22 non-PH patients. In non-PH children, P(Ox) and β(CaOx) decreased to normal within three weeks after successful kidney transplantation, whereas the levels still remained elevated seven months after combined liver-kidney transplantation in two PH 1 patients. Conclusion. Systemic oxalosis in PH 1 children with ESRD is due to higher P(Ox) and β(CaOx) levels. As β(CaOx) remained supersaturated in PH 1 even after aggressive HD, oxalate accumulation increases, and CaOx tissue deposition occurs. Therefore, sufficient reduction of P(Ox) and β(CaOx) is crucial in PH 1 and might only be achieved by early, preemptive, combined liver-kidney transplantation or liver transplantation alone.

KW - Crystal deposition

KW - Liver

KW - Oxalosis

KW - Renal replacement therapy

KW - Solid organ transplantation

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