Plasma carboxy-terminal peptide of procollagen type I is an independent predictor of diastolic function in patients with advanced systolic heart failure

Chanwit Roongsritong*, Ashish Sadhu, Mika Pierce, Rishi Raj, Jan Simoni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Severe diastolic dysfunction has important clinical implications in advanced systolic heart failure. The authors investigated whether a marker of fibrosis, serum carboxy-terminal peptide of procollagen type I (PICP) is a major determinant of diastolic function in 40 patients with heart failure and ejection fraction <35%. Patients with unstable heart failure or ischemic symptoms were excluded. The authors found PICP to be an independent predictor of diastolic function in addition to age and pulmonary artery systolic pressure. The authors' findings suggest that studies evaluating whether therapy that improves myocardial fibrosis could have a favorable impact on diastolic function in this population are warranted.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalCongestive Heart Failure
Volume14
Issue number6
DOIs
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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