Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

Adam B. Weiner; Thiago Vidotto; Yang Liu; Adrianna A. Mendes; Daniela C. Salles; Farzana A. Faisal; Sanjana Murali; Matthew McFarlane; Eddie L. Imada; Xin Zhao; Ziwen Li; Elai Davicioni; Luigi Marchionni; Arul M. Chinnaiyan; Stephen J. Freedland; Daniel E. Spratt; Jennifer D. Wu; Tamara L. Lotan; Edward M. Schaeffer

doi:10.1038/s41467-021-21245-w

Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

Adam B. Weiner, Thiago Vidotto, Yang Liu, Adrianna A. Mendes, Daniela C. Salles, Farzana A. Faisal, Sanjana Murali, Matthew McFarlane, Eddie L. Imada, Xin Zhao, Ziwen Li, Elai Davicioni, Luigi Marchionni, Arul M. Chinnaiyan, Stephen J. Freedland, Daniel E. Spratt, Jennifer D. Wu, Tamara L. Lotan, Edward M. Schaeffer^*

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

Original language	English (US)
Article number	935
Journal	Nature communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-21245-w
State	Published - Dec 1 2021

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-021-21245-w

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Weiner, A. B., Vidotto, T., Liu, Y., Mendes, A. A., Salles, D. C., Faisal, F. A., Murali, S., McFarlane, M., Imada, E. L., Zhao, X., Li, Z., Davicioni, E., Marchionni, L., Chinnaiyan, A. M., Freedland, S. J., Spratt, D. E., Wu, J. D., Lotan, T. L., & Schaeffer, E. M. (2021). Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. Nature communications, 12(1), [935]. https://doi.org/10.1038/s41467-021-21245-w

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title = "Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes",

abstract = "Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.",

author = "Weiner, {Adam B.} and Thiago Vidotto and Yang Liu and Mendes, {Adrianna A.} and Salles, {Daniela C.} and Faisal, {Farzana A.} and Sanjana Murali and Matthew McFarlane and Imada, {Eddie L.} and Xin Zhao and Ziwen Li and Elai Davicioni and Luigi Marchionni and Chinnaiyan, {Arul M.} and Freedland, {Stephen J.} and Spratt, {Daniel E.} and Wu, {Jennifer D.} and Lotan, {Tamara L.} and Schaeffer, {Edward M.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

day = "1",

doi = "10.1038/s41467-021-21245-w",

language = "English (US)",

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Weiner, AB, Vidotto, T, Liu, Y, Mendes, AA, Salles, DC, Faisal, FA, Murali, S, McFarlane, M, Imada, EL, Zhao, X, Li, Z, Davicioni, E, Marchionni, L, Chinnaiyan, AM, Freedland, SJ, Spratt, DE, Wu, JD, Lotan, TL & Schaeffer, EM 2021, 'Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes', Nature communications, vol. 12, no. 1, 935. https://doi.org/10.1038/s41467-021-21245-w

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T1 - Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

AU - Weiner, Adam B.

AU - Vidotto, Thiago

AU - Liu, Yang

AU - Mendes, Adrianna A.

AU - Salles, Daniela C.

AU - Faisal, Farzana A.

AU - Murali, Sanjana

AU - McFarlane, Matthew

AU - Imada, Eddie L.

AU - Zhao, Xin

AU - Li, Ziwen

AU - Davicioni, Elai

AU - Marchionni, Luigi

AU - Chinnaiyan, Arul M.

AU - Freedland, Stephen J.

AU - Spratt, Daniel E.

AU - Wu, Jennifer D.

AU - Lotan, Tamara L.

AU - Schaeffer, Edward M.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

AB - Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

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Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

Abstract

ASJC Scopus subject areas

UN SDGs

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