Plasma CPK levels in monozygotic and dizygotic twins discordant for schizophrenia

Philip S. Holzman*, Herbert Y. Meltzer, Einar Kringlen, Deborah L. Levy, Shelby J. Haberman, John M. Davis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Plasma creatine phosphokinase (CPK) activity was determined in single samples of 9 monozygotic and 14 dizygotic twin pairs chosen from an earlier study on the basis of their having been discordant for clinical schizophrenia. The correlations within the MZ pairs was 0.89, and within the DZ pairs was 0.40. The results support a conclusion of genetic control of plasma CPK activity. The mean levels of activity were not abnormal, however.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalJournal of Psychiatric Research
Issue number2
StatePublished - 1979

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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