Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation

Mark Gorelik*, David C. Wilson, Yona K. Cloonan, Stanford T. Shulman, Raphael Hirsch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objective: To determine whether plasma levels of follistatin-like protein 1 (FSTL-1), a pro-inflammatory protein produced by mesenchymal tissue, including cardiac myocytes, correlate with the development of Kawasaki disease (KD) and coronary artery aneurysms (CAA). Study design: FSTL-1 plasma levels were measured serially with enzyme-linked immunosorbent assay in 48 patients with KD at time of diagnosis and, when available, 2 weeks, 6 weeks, and 6 months after onset of disease. These were compared with FSTL-1 plasma levels in 23 control subjects. Data were analyzed with generalized estimating equations. Results: Plasma FSTL-1 levels were elevated in patients with acute KD compared with control subjects (P =.0086). FSTL-1 levels remained significantly elevated at 2 weeks after disease onset, but returned to control levels by 6 months. Seven patients with CAA had significantly higher FSTL-1 levels at the time of diagnosis than patients in whom aneurysms did not develop (P =.0018). Sensitivity and specificity rates for CAA at a specific FSTL-1 cutoff point (178 ng/mL) were 85% and 71%. Conclusions: Plasma levels of FSTL-1 are elevated in acute KD and may predict cardiac morbidity in this disease. These results suggest a possible role for FSTL-1 in the formation of CAAs.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalJournal of Pediatrics
Volume161
Issue number1
DOIs
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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