TY - JOUR
T1 - Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation
AU - Gorelik, Mark
AU - Wilson, David C.
AU - Cloonan, Yona K.
AU - Shulman, Stanford T.
AU - Hirsch, Raphael
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To determine whether plasma levels of follistatin-like protein 1 (FSTL-1), a pro-inflammatory protein produced by mesenchymal tissue, including cardiac myocytes, correlate with the development of Kawasaki disease (KD) and coronary artery aneurysms (CAA). Study design: FSTL-1 plasma levels were measured serially with enzyme-linked immunosorbent assay in 48 patients with KD at time of diagnosis and, when available, 2 weeks, 6 weeks, and 6 months after onset of disease. These were compared with FSTL-1 plasma levels in 23 control subjects. Data were analyzed with generalized estimating equations. Results: Plasma FSTL-1 levels were elevated in patients with acute KD compared with control subjects (P =.0086). FSTL-1 levels remained significantly elevated at 2 weeks after disease onset, but returned to control levels by 6 months. Seven patients with CAA had significantly higher FSTL-1 levels at the time of diagnosis than patients in whom aneurysms did not develop (P =.0018). Sensitivity and specificity rates for CAA at a specific FSTL-1 cutoff point (178 ng/mL) were 85% and 71%. Conclusions: Plasma levels of FSTL-1 are elevated in acute KD and may predict cardiac morbidity in this disease. These results suggest a possible role for FSTL-1 in the formation of CAAs.
AB - Objective: To determine whether plasma levels of follistatin-like protein 1 (FSTL-1), a pro-inflammatory protein produced by mesenchymal tissue, including cardiac myocytes, correlate with the development of Kawasaki disease (KD) and coronary artery aneurysms (CAA). Study design: FSTL-1 plasma levels were measured serially with enzyme-linked immunosorbent assay in 48 patients with KD at time of diagnosis and, when available, 2 weeks, 6 weeks, and 6 months after onset of disease. These were compared with FSTL-1 plasma levels in 23 control subjects. Data were analyzed with generalized estimating equations. Results: Plasma FSTL-1 levels were elevated in patients with acute KD compared with control subjects (P =.0086). FSTL-1 levels remained significantly elevated at 2 weeks after disease onset, but returned to control levels by 6 months. Seven patients with CAA had significantly higher FSTL-1 levels at the time of diagnosis than patients in whom aneurysms did not develop (P =.0018). Sensitivity and specificity rates for CAA at a specific FSTL-1 cutoff point (178 ng/mL) were 85% and 71%. Conclusions: Plasma levels of FSTL-1 are elevated in acute KD and may predict cardiac morbidity in this disease. These results suggest a possible role for FSTL-1 in the formation of CAAs.
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U2 - 10.1016/j.jpeds.2012.01.011
DO - 10.1016/j.jpeds.2012.01.011
M3 - Article
C2 - 22316625
AN - SCOPUS:84862765713
SN - 0022-3476
VL - 161
SP - 116
EP - 119
JO - journal of pediatrics
JF - journal of pediatrics
IS - 1
ER -