Plasma gelsolin and circulating actin correlate with hemodialysis mortality

Po Shun Lee, Kartik Sampath, S. Ananth Karumanchi, Hector Tamez, Ishir Bhan, Tamara Isakova, Orlando M. Gutierrez, Myles Wolf, Yuchiao Chang, Thomas P. Stossel, Ravi Thadhani*

*Corresponding author for this work

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Plasma gelsolin (pGSN) binds actin and bioactive mediators to localize inflammation. Low pGSN correlates with adverse outcomes in acute injury, whereas administration of recombinant pGSN reduces mortality in experimental sepsis. We found that mean pGSN levels of 150 patients randomly selected from 10,044 starting chronic hemodialysis were 140 ± 42 mg/L, 30 to 50% lower than levels reported for healthy individuals. In a larger sample, we performed a case-control analysis to evaluate the relationship of pGSN and circulating actin with mortality; pGSN levels were significantly lower in 114 patients who died within 1 yr of dialysis initiation than in 109 survivors (117 ± 38 mg/L versus 147 ± 42 mg/L, P < 0.001). pGSN levels had a graded, inverse relationship with 1-yr mortality, such that patients with pGSN <130 mg/L experienced a >3-fold risk for mortality compared with those with pGSN ≥150 mg/L. The 69% of patients with detectable circulating actin had lower pGSN levels than those without (127 ± 45 mg/L versus 141 ± 36 mg/L, P = 0.026). Compared with patients who had elevated pGSN and no detectable actin, those with low pGSN levels and detectable actin had markedly increased mortality (odds ratio 9.8, 95% confidence interval 2.9 to 33.5). Worsening renal function correlated with pGSN decline in 53 subjects with CKD not on dialysis. In summary, low pGSN and detectable circulating actin identify chronic hemodialysis patients at highest risk for 1-yr mortality.

Original languageEnglish (US)
Pages (from-to)1140-1148
Number of pages9
JournalJournal of the American Society of Nephrology
Volume20
Issue number5
DOIs
StatePublished - May 2009

ASJC Scopus subject areas

  • Nephrology

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    Lee, P. S., Sampath, K., Karumanchi, S. A., Tamez, H., Bhan, I., Isakova, T., Gutierrez, O. M., Wolf, M., Chang, Y., Stossel, T. P., & Thadhani, R. (2009). Plasma gelsolin and circulating actin correlate with hemodialysis mortality. Journal of the American Society of Nephrology, 20(5), 1140-1148. https://doi.org/10.1681/ASN.2008091008