Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics independent of albuminuria

Jennie Lin, Muredach P. Reilly, Karen Terembula, F. Perry Wilson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: CKD, an independent risk factor for CV disease, increases mortality in T2DM. Treating modifiable CV risk factors decreases mortality in diabetics with microalbuminuria, but the role of early CV prevention in diabetics with mild CKD by GFR criteria alone remains unclear. The purpose of this study was to probe whether T2DM patients with mild GFR impairment have atherogenic lipid profiles compared to diabetic counterparts with normal renal function. Methods: In the Penn Diabetes Heart Study (PDHS), a single-center observational cohort of T2DM patients without clinical CVD, cross-sectional analyses were performed for directly measured lipid fractions in 1852 subjects with eGFR.60 mL/ min/1.73 m2 determined by the CKD-EPI equation (n51852). Unadjusted and multivariable analyses of eGFR association with log-transformed lipid parameters in incremental linear and logistic regression models (with eGFR 90 mL/min/1.73 m2 as a cut-point) were performed. Results: Mild GFR impairment (eGFR 60-90 mL/min/1.73 m2, median urinary ACR 5.25 mg/g) was associated with higher log-transformed Lp(a) values (OR 1.17, p50.005) and with clinically atherogenic Lp(a) levels above 30 mg/dL (OR 1.35, p50.013) even after full adjustment for demographics, medications, metabolic parameters, and albuminuria. Logistic regression demonstrated a trend towards significance between worse kidney function and apoB (p50.17) as well as apoC-III (p50.067) in the fully adjusted model.

Original languageEnglish (US)
Article numbere114397
JournalPloS one
Issue number12
StatePublished - Dec 9 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • General
  • Biochemistry, Genetics and Molecular Biology(all)


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