Plasma membrane protein sorting in epithelial cells: Do secretory pathways hold the key?

James R. Bartles*, Ann L. Hubbard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

The Madin-Darby canine kidney (MDCK) cell sorts newly synthesized apical and basolateral plasma membrane proteins intracellularly and then ships them directly to the correct plasma membrane domains, whereas the rat hepatocyte sorts apical and basolateral proteins after their arrival at the basolateral domain of the plasma membrane and then employs a transcytotic mechanism to deliver the apical proteins to the apical domain. This difference in plasma membrane protein sorting pathways may relate to the observation that the hepatocyte, unlike the MDCK cell, does not have an apically directed secretory pathway.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalTrends in Biochemical Sciences
Volume13
Issue number5
DOIs
StatePublished - May 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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