Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia

John W. Newcomer; Sherry J. Riney; Sophia Vinogradov; John G. Csernansky

doi:10.1016/0165-1781(92)90001-J

Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia

John W. Newcomer, Sherry J. Riney, Sophia Vinogradov, John G. Csernansky

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Measurement of plasma prolactin (PRL) concentration and plasma homovanillic acid (HVA) concentration was performed in 24 patients with schizophrenia during maintenance haloperidol treatment. A significant inverse correlation was found between plasma PRL and ratings of both dyskinesia and thought disorder. Plasma PRL was also correlated with negative symptoms. No relationship was found between plasma HVA and any symptom grouping. Twelve patients received an apomorphine challenge; a trend toward a significant inverse relationship was found between baseline dyskinesia and apomorphine-induced decreases in plasma PRL. Plasma PRL and plasma HVA may reflect different elements of dopamine function in the central nervous system during maintenance treatment; plasma PRL may be the useful marker under these conditions.

Original language	English (US)
Pages (from-to)	191-202
Number of pages	12
Journal	Psychiatry Research
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(92)90001-J
State	Published - Mar 1992

Keywords

Neuroleptic treatment
apomorphine
dopamine
tardive dyskinesia
thought disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-1781(92)90001-J

Cite this

@article{2c80ddb6bc6e4179beebbb56c98b2359,

title = "Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia",

abstract = "Measurement of plasma prolactin (PRL) concentration and plasma homovanillic acid (HVA) concentration was performed in 24 patients with schizophrenia during maintenance haloperidol treatment. A significant inverse correlation was found between plasma PRL and ratings of both dyskinesia and thought disorder. Plasma PRL was also correlated with negative symptoms. No relationship was found between plasma HVA and any symptom grouping. Twelve patients received an apomorphine challenge; a trend toward a significant inverse relationship was found between baseline dyskinesia and apomorphine-induced decreases in plasma PRL. Plasma PRL and plasma HVA may reflect different elements of dopamine function in the central nervous system during maintenance treatment; plasma PRL may be the useful marker under these conditions.",

keywords = "Neuroleptic treatment, apomorphine, dopamine, tardive dyskinesia, thought disorder",

author = "Newcomer, {John W.} and Riney, {Sherry J.} and Sophia Vinogradov and Csernansky, {John G.}",

year = "1992",

month = mar,

doi = "10.1016/0165-1781(92)90001-J",

language = "English (US)",

volume = "41",

pages = "191--202",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia

AU - Newcomer, John W.

AU - Riney, Sherry J.

AU - Vinogradov, Sophia

AU - Csernansky, John G.

PY - 1992/3

Y1 - 1992/3

N2 - Measurement of plasma prolactin (PRL) concentration and plasma homovanillic acid (HVA) concentration was performed in 24 patients with schizophrenia during maintenance haloperidol treatment. A significant inverse correlation was found between plasma PRL and ratings of both dyskinesia and thought disorder. Plasma PRL was also correlated with negative symptoms. No relationship was found between plasma HVA and any symptom grouping. Twelve patients received an apomorphine challenge; a trend toward a significant inverse relationship was found between baseline dyskinesia and apomorphine-induced decreases in plasma PRL. Plasma PRL and plasma HVA may reflect different elements of dopamine function in the central nervous system during maintenance treatment; plasma PRL may be the useful marker under these conditions.

AB - Measurement of plasma prolactin (PRL) concentration and plasma homovanillic acid (HVA) concentration was performed in 24 patients with schizophrenia during maintenance haloperidol treatment. A significant inverse correlation was found between plasma PRL and ratings of both dyskinesia and thought disorder. Plasma PRL was also correlated with negative symptoms. No relationship was found between plasma HVA and any symptom grouping. Twelve patients received an apomorphine challenge; a trend toward a significant inverse relationship was found between baseline dyskinesia and apomorphine-induced decreases in plasma PRL. Plasma PRL and plasma HVA may reflect different elements of dopamine function in the central nervous system during maintenance treatment; plasma PRL may be the useful marker under these conditions.

KW - Neuroleptic treatment

KW - apomorphine

KW - dopamine

KW - tardive dyskinesia

KW - thought disorder

UR - http://www.scopus.com/inward/record.url?scp=0026521546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026521546&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(92)90001-J

DO - 10.1016/0165-1781(92)90001-J

M3 - Article

C2 - 1594706

AN - SCOPUS:0026521546

SN - 0165-1781

VL - 41

SP - 191

EP - 202

JO - Psychiatry Research

JF - Psychiatry Research

IS - 3

ER -

Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this