Plasma prolactin response to domperidone in acute schizophrenia and schizophreniform illness

Dina Nerozzi*, Armando Magnani, Vincenzo Sforza, Elena Scaramucci, Marco Cerilli, Costanzo Moretti, Gaetano Frajese, Italo Antonozzi, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The prolactin (PRL) response to 20 mg of domperidone, a peripheral dopamine (DA) blocking agent, was evaluated in a group of 16 drug-free, acute, young schizophreniform and schizophrenic males and in a group of age-matched normal males. Although basal plasma PRL levels were normal, the PRL responses following domperidone were blunted in both patient groups. The PRL response was more blunted in the schizophreniform patients than in the schizophrenic patients. Possible explanations for these results include pharmacokinetic factors or abnormalities of the pituitary D2 DA receptors.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalPsychiatry Research
Volume34
Issue number2
DOIs
StatePublished - Nov 1990

Keywords

  • D receptors
  • D receptors
  • Schizophrenia
  • domperidone
  • dopamine
  • prolactin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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