Plasma vitamin D metabolite levels in pregnant and nonpregnant ewes

Susan K. Paulson; Craig B. Langman

doi:10.1016/0300-9629(90)90703-U

Plasma vitamin D metabolite levels in pregnant and nonpregnant ewes

Susan K. Paulson^*, Craig B. Langman

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

1. 1. Maternal calcium homeostasis during pregnancy is strained due to fetal mineral requirements for bone formation. 2. 2. In most species, the mother adjusts to the mineral requirements of the fetus with alterations in her metabolism of vitamin D that include a decrease in plasma 25-(OH)D levels and an increase in circulating levels of the hormone, 1,25-(OH)₂D. 3. 3. Plasma 25-(OH)D and 1,25-(OH)₂D levels in adult male, adult female and pregnant sheep were measured by specific radioreceptor binding assays. 4. 4. Pregnancy did not alter circulating levels of 25-(OH)D or 1,25-(OH)₂D in the sheep. 5. 5. The pregnant ewe differs from all species studied to date in that maternal plasma 1,25-(OH)₂D levels do not rise as a result of pregnancy.

Original language	English (US)
Pages (from-to)	347-349
Number of pages	3
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/0300-9629(90)90703-U
State	Published - 1990

ASJC Scopus subject areas

Physiology

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10.1016/0300-9629(90)90703-U

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abstract = "1. 1. Maternal calcium homeostasis during pregnancy is strained due to fetal mineral requirements for bone formation. 2. 2. In most species, the mother adjusts to the mineral requirements of the fetus with alterations in her metabolism of vitamin D that include a decrease in plasma 25-(OH)D levels and an increase in circulating levels of the hormone, 1,25-(OH)2D. 3. 3. Plasma 25-(OH)D and 1,25-(OH)2D levels in adult male, adult female and pregnant sheep were measured by specific radioreceptor binding assays. 4. 4. Pregnancy did not alter circulating levels of 25-(OH)D or 1,25-(OH)2D in the sheep. 5. 5. The pregnant ewe differs from all species studied to date in that maternal plasma 1,25-(OH)2D levels do not rise as a result of pregnancy.",

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AB - 1. 1. Maternal calcium homeostasis during pregnancy is strained due to fetal mineral requirements for bone formation. 2. 2. In most species, the mother adjusts to the mineral requirements of the fetus with alterations in her metabolism of vitamin D that include a decrease in plasma 25-(OH)D levels and an increase in circulating levels of the hormone, 1,25-(OH)2D. 3. 3. Plasma 25-(OH)D and 1,25-(OH)2D levels in adult male, adult female and pregnant sheep were measured by specific radioreceptor binding assays. 4. 4. Pregnancy did not alter circulating levels of 25-(OH)D or 1,25-(OH)2D in the sheep. 5. 5. The pregnant ewe differs from all species studied to date in that maternal plasma 1,25-(OH)2D levels do not rise as a result of pregnancy.

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Plasma vitamin D metabolite levels in pregnant and nonpregnant ewes

Abstract

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