Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles

Xuan Jiang, Wei Qu, Deng Pan, Yong Ren, John Michael Williford, Honggang Cui, Erik Luijten*, Hai Quan Mao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalAdvanced Materials
Volume25
Issue number2
DOIs
StatePublished - Jan 11 2013

Keywords

  • gene delivery
  • plasmid DNA
  • shape control
  • solvent polarity
  • templated self-assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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