Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles

Xuan Jiang; Wei Qu; Deng Pan; Yong Ren; John Michael Williford; Honggang Cui; Erik Luijten; Hai Quan Mao

doi:10.1002/adma.201202932

Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles

Xuan Jiang, Wei Qu, Deng Pan, Yong Ren, John Michael Williford, Honggang Cui, Erik Luijten^*, Hai Quan Mao

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

Original language	English (US)
Pages (from-to)	227-232
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	2
DOIs	https://doi.org/10.1002/adma.201202932
State	Published - Jan 11 2013

Keywords

gene delivery
plasmid DNA
shape control
solvent polarity
templated self-assembly

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201202932

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title = "Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles",

abstract = "DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.",

keywords = "gene delivery, plasmid DNA, shape control, solvent polarity, templated self-assembly",

author = "Xuan Jiang and Wei Qu and Deng Pan and Yong Ren and Williford, {John Michael} and Honggang Cui and Erik Luijten and Mao, {Hai Quan}",

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T1 - Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles

AU - Jiang, Xuan

AU - Qu, Wei

AU - Pan, Deng

AU - Ren, Yong

AU - Williford, John Michael

AU - Cui, Honggang

AU - Luijten, Erik

AU - Mao, Hai Quan

PY - 2013/1/11

Y1 - 2013/1/11

N2 - DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

AB - DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

KW - gene delivery

KW - plasmid DNA

KW - shape control

KW - solvent polarity

KW - templated self-assembly

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Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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