Plasminogen activator inhibitor-1 antagonist TM5484 attenuates demyelination and axonal degeneration in a mice model of multiple sclerosis

Agriculture & Biology

• plasminogen activator inhibitors 95%
• sclerosis 88%
• animal models 57%
• antagonists 56%
• blood-brain barrier 28%
• central nervous system 21%
• mice 18%
• central nervous system diseases 17%
• methylprednisolone 16%
• screening 15%
• neurotrophins 15%
• choline acetyltransferase 14%
• disease models 14%
• encephalitis 13%
• paralysis 12%
• fibrinogen 12%
• spinal cord 11%
• oral administration 11%
• inflammation 9%
• neurons 9%
• brain 7%

Medicine & Life Sciences

• Plasminogen Activator Inhibitor 1 73%
• Demyelinating Diseases 68%
• Multiple Sclerosis 57%
• Blood-Brain Barrier 21%
• Central Nervous System 16%
• Fingolimod Hydrochloride 15%
• Choline O-Acetyltransferase 13%
• Autoimmune Experimental Encephalomyelitis 12%
• Methylprednisolone 12%
• Central Nervous System Diseases 11%
• Brain-Derived Neurotrophic Factor 11%
• Paralysis 10%
• Fibrinogen 10%
• In Vitro Techniques 9%
• Oral Administration 9%
• Spinal Cord 8%
• Animal Models 7%
• Neurons 6%
• Inflammation 6%

Chemical Compounds

• Plasminogen Activator Inhibitor 100%
• Antagonist 60%
• 6-Methylprednisolone 22%
• Fingolimod 20%
• Cord 13%
• Choline 11%
• Marker 9%
• Protective 9%