Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Douglas E Vaughan*, Rahul Rai, Sadiya Sana Khan, Mesut Eren, Asish K Ghosh

*Corresponding author for this work

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

Original languageEnglish (US)
Pages (from-to)1446-1452
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume37
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Plasminogen Activator Inhibitor 1
Cell Aging
Serine Proteinase Inhibitors
Plasminogen Activators
Comorbidity
Homeostasis
Pathology

Keywords

  • aging
  • arteriosclerosis
  • endothelial dysfunction
  • plasminogen activator inhibitor-1
  • thrombosis
  • transforming growth factor-β

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence",
abstract = "PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.",
keywords = "aging, arteriosclerosis, endothelial dysfunction, plasminogen activator inhibitor-1, thrombosis, transforming growth factor-β",
author = "Vaughan, {Douglas E} and Rahul Rai and Khan, {Sadiya Sana} and Mesut Eren and Ghosh, {Asish K}",
year = "2017",
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T1 - Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

AU - Vaughan, Douglas E

AU - Rai, Rahul

AU - Khan, Sadiya Sana

AU - Eren, Mesut

AU - Ghosh, Asish K

PY - 2017/8/1

Y1 - 2017/8/1

N2 - PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

AB - PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

KW - aging

KW - arteriosclerosis

KW - endothelial dysfunction

KW - plasminogen activator inhibitor-1

KW - thrombosis

KW - transforming growth factor-β

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DO - 10.1161/ATVBAHA.117.309451

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JO - Arteriosclerosis, Thrombosis, and Vascular Biology

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