Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Douglas E. Vaughan*, Rahul Rai, Sadiya S. Khan, Mesut Eren, Asish K. Ghosh

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

Original languageEnglish (US)
Pages (from-to)1446-1452
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume37
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • aging
  • arteriosclerosis
  • endothelial dysfunction
  • plasminogen activator inhibitor-1
  • thrombosis
  • transforming growth factor-β

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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