Plasminogen activator inhibitor 1: Molecular aspects and clinical importance

Douglas E. Vaughan

doi:10.1007/BF01062709

Plasminogen activator inhibitor 1: Molecular aspects and clinical importance

Douglas E. Vaughan^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of plasminogen activation in plasma and in the blood vessel wall. PAI-1 exhibits distinctive structural and functional properties that have been extensively studied over the past decade. Aside from the physiological role of PAI-1, there is accumulating evidence that increased production of PAI-1 may contribute to the development of ischemic cardiovascular disease. Efforts are now underway to develop and test specific inhibitors of PAI-1.

Original language	English (US)
Pages (from-to)	187-193
Number of pages	7
Journal	Journal of Thrombosis and Thrombolysis: An International Journal for Clinicians and Scientists
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/BF01062709
State	Published - Sep 1995

Keywords

fibrinolysis
plasminogen activator inhibitor-1 (PAI-1)
serpin
thrombolysis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01062709

Cite this

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title = "Plasminogen activator inhibitor 1: Molecular aspects and clinical importance",

abstract = "Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of plasminogen activation in plasma and in the blood vessel wall. PAI-1 exhibits distinctive structural and functional properties that have been extensively studied over the past decade. Aside from the physiological role of PAI-1, there is accumulating evidence that increased production of PAI-1 may contribute to the development of ischemic cardiovascular disease. Efforts are now underway to develop and test specific inhibitors of PAI-1.",

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AU - Vaughan, Douglas E.

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AB - Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of plasminogen activation in plasma and in the blood vessel wall. PAI-1 exhibits distinctive structural and functional properties that have been extensively studied over the past decade. Aside from the physiological role of PAI-1, there is accumulating evidence that increased production of PAI-1 may contribute to the development of ischemic cardiovascular disease. Efforts are now underway to develop and test specific inhibitors of PAI-1.

KW - fibrinolysis

KW - plasminogen activator inhibitor-1 (PAI-1)

KW - serpin

KW - thrombolysis

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IS - 3

ER -

Plasminogen activator inhibitor 1: Molecular aspects and clinical importance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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