Plasminogen activator inhibitor 1: Molecular aspects and clinical importance

Douglas E. Vaughan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of plasminogen activation in plasma and in the blood vessel wall. PAI-1 exhibits distinctive structural and functional properties that have been extensively studied over the past decade. Aside from the physiological role of PAI-1, there is accumulating evidence that increased production of PAI-1 may contribute to the development of ischemic cardiovascular disease. Efforts are now underway to develop and test specific inhibitors of PAI-1.

Original languageEnglish (US)
Pages (from-to)187-193
Number of pages7
JournalJournal of Thrombosis and Thrombolysis: An International Journal for Clinicians and Scientists
Volume2
Issue number3
DOIs
StatePublished - Jan 1 1995

Keywords

  • fibrinolysis
  • plasminogen activator inhibitor-1 (PAI-1)
  • serpin
  • thrombolysis

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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