TY - JOUR
T1 - Plasminogen activator inhibitor type 1 in diabetes and hypertension
AU - Litchfield, W. Reid
AU - Brown, Nancy
AU - Vaughan, Douglas E.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of tissue plasminogen activator and a crucial element of the endogenous fibrinolytic system. Elevated levels of PAI-1 appear to be associated with an increased incidence of myocardial infarction and increased cardiovascular risk. Strong associations between PAI-1 and hypertriglyceridemia, hyperinsulinemia, and hypertension suggest that part of the increase in cardiovascular risk seen in individuals with these conditions may be related to elevated levels of PAI-1. The increased cardiovascular risk seen in those with essential hypertension may relate to an independent interaction between the renin-angiotensin system and PAI-1. The extent to which PAI-1 explains the increased incidence of cardiovascular disease in diabetic and hypertensive patients, as well as the extent to which this incidence can be reduced, remains unclear.
AB - Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of tissue plasminogen activator and a crucial element of the endogenous fibrinolytic system. Elevated levels of PAI-1 appear to be associated with an increased incidence of myocardial infarction and increased cardiovascular risk. Strong associations between PAI-1 and hypertriglyceridemia, hyperinsulinemia, and hypertension suggest that part of the increase in cardiovascular risk seen in individuals with these conditions may be related to elevated levels of PAI-1. The increased cardiovascular risk seen in those with essential hypertension may relate to an independent interaction between the renin-angiotensin system and PAI-1. The extent to which PAI-1 explains the increased incidence of cardiovascular disease in diabetic and hypertensive patients, as well as the extent to which this incidence can be reduced, remains unclear.
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U2 - 10.1097/00060793-199706000-00009
DO - 10.1097/00060793-199706000-00009
M3 - Article
AN - SCOPUS:0005453518
VL - 4
SP - 233
EP - 238
JO - Current Opinion in Endocrinology, Diabetes and Obesity
JF - Current Opinion in Endocrinology, Diabetes and Obesity
SN - 1752-296X
IS - 3
ER -