Abstract
We examined a variety of hemostatic functions in a subset of patients participating in a multicenter trial of rt-PA in the treatment of DVT. There were declines in systemic levels of plasminogen and alpha2-antiplasmin at 24 hours following therapy. Additionally, levels of protein C antigen and protein C activity were also seen to decrease over the same time course. We propose that therapy with rt-PA has more systemic effects than previously thought and suggest that the effect on protein C may have some role in reocclusion following thrombolysis.
Original language | English (US) |
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Pages (from-to) | 242-244 |
Number of pages | 3 |
Journal | Seminars in thrombosis and hemostasis |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - 1990 |
ASJC Scopus subject areas
- Hematology
- Cardiology and Cardiovascular Medicine