Plasminogen, alpha2-antiplasmin, and protein C decline following infusions of recombinant tissue plasminogen activator

G. Yang, David Green

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We examined a variety of hemostatic functions in a subset of patients participating in a multicenter trial of rt-PA in the treatment of DVT. There were declines in systemic levels of plasminogen and alpha2-antiplasmin at 24 hours following therapy. Additionally, levels of protein C antigen and protein C activity were also seen to decrease over the same time course. We propose that therapy with rt-PA has more systemic effects than previously thought and suggest that the effect on protein C may have some role in reocclusion following thrombolysis.

Original languageEnglish (US)
Pages (from-to)242-244
Number of pages3
JournalSeminars in Thrombosis and Hemostasis
Volume16
Issue number3
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Plasminogen, alpha<sub>2</sub>-antiplasmin, and protein C decline following infusions of recombinant tissue plasminogen activator'. Together they form a unique fingerprint.

Cite this