We examined a variety of hemostatic functions in a subset of patients participating in a multicenter trial of rt-PA in the treatment of DVT. There were declines in systemic levels of plasminogen and alpha2-antiplasmin at 24 hours following therapy. Additionally, levels of protein C antigen and protein C activity were also seen to decrease over the same time course. We propose that therapy with rt-PA has more systemic effects than previously thought and suggest that the effect on protein C may have some role in reocclusion following thrombolysis.
|Original language||English (US)|
|Number of pages||3|
|Journal||Seminars in Thrombosis and Hemostasis|
|State||Published - Jan 1 1990|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine