Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.
Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.
Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.
Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology