Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

Lei Li; Ya Chao Yao; Xiao Qiong Gu; Di Che; Cai Qi Ma; Zhi Yu Dai; Cen Li; Ti Zhou; Wei Bin Cai; Zhong Han Yang; Xia Yang; Guo Quan Gao

doi:10.1074/jbc.M114.567792

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

Lei Li, Ya Chao Yao, Xiao Qiong Gu, Di Che, Cai Qi Ma, Zhi Yu Dai, Cen Li, Ti Zhou, Wei Bin Cai, Zhong Han Yang, Xia Yang, Guo Quan Gao^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.

Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.

Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.

Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

Original language	English (US)
Pages (from-to)	32628-32638
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M114.567792
State	Published - Nov 21 2014

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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Li, L., Yao, Y. C., Gu, X. Q., Che, D., Ma, C. Q., Dai, Z. Y., Li, C., Zhou, T., Cai, W. B., Yang, Z. H., Yang, X., & Gao, G. Q. (2014). Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. Journal of Biological Chemistry, 289(47), 32628-32638. https://doi.org/10.1074/jbc.M114.567792

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title = "Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop",

abstract = "Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.Conclusion: A positive feedback loop of {"}VDAC1-AKT-GSK3 VDAC1{"} mediates K5-induced EC apoptosis.Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.",

author = "Lei Li and Yao, {Ya Chao} and Gu, {Xiao Qiong} and Di Che and Ma, {Cai Qi} and Dai, {Zhi Yu} and Cen Li and Ti Zhou and Cai, {Wei Bin} and Yang, {Zhong Han} and Xia Yang and Gao, {Guo Quan}",

year = "2014",

month = nov,

day = "21",

doi = "10.1074/jbc.M114.567792",

language = "English (US)",

volume = "289",

pages = "32628--32638",

journal = "Journal of Biological Chemistry",

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publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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TY - JOUR

T1 - Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

AU - Li, Lei

AU - Yao, Ya Chao

AU - Gu, Xiao Qiong

AU - Che, Di

AU - Ma, Cai Qi

AU - Dai, Zhi Yu

AU - Li, Cen

AU - Zhou, Ti

AU - Cai, Wei Bin

AU - Yang, Zhong Han

AU - Yang, Xia

AU - Gao, Guo Quan

PY - 2014/11/21

Y1 - 2014/11/21

N2 - Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

AB - Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

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DO - 10.1074/jbc.M114.567792

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JF - Journal of Biological Chemistry

IS - 47

ER -

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

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