Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS)

Ji Eun Park; Nihan Yonet-Tanyeri; Emma Vander Ende; Anne-Isabelle Henry Baruch; Bethany E. Perez White; Milan Mrksich; Richard P Van Duyne

doi:10.1021/acs.nanolett.9b02070

Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS)

Ji Eun Park, Nihan Yonet-Tanyeri, Emma Vander Ende, Anne-Isabelle Henry Baruch, Bethany E. Perez White, Milan Mrksich^*, Richard P Van Duyne

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a sensitive, chemically specific, and short-time response probing method with significant potential in biomedical sensing. This paper reports the integration of SERS with microneedle arrays as a minimally invasive platform for chemical sensing, with a particular view toward sensing in interstitial fluid (ISF). Microneedle arrays were fabricated from a commercial polymeric adhesive and coated with plasmonically active gold nanorods that were functionalized with the pH-sensitive molecule 4-mercaptobenzoic acid. This sensor can quantitate pH over a range of 5 to 9 and can detect pH levels in an agar gel skin phantom and in human skin in situ. The sensor array is stable and mechanically robust in that it exhibits no loss in SERS activity after multiple punches through an agar gel skin phantom and human skin or after a month-long incubation in phosphate-buffered saline. This work is the first to integrate SERS-active nanoparticles with polymeric microneedle arrays and to demonstrate in situ sensing with this platform.

Original language	English (US)
Pages (from-to)	6862-6868
Number of pages	7
Journal	Nano letters
Volume	19
Issue number	10
DOIs	https://doi.org/10.1021/acs.nanolett.9b02070
State	Published - Oct 9 2019

Funding

The authors thank Ian Rubinoff and Pengxiao Hao with their support with OCT, Tirzah Abbott with her help with SEM, Eric J. Berns, Vitor Brasiliense, and Gyeongwon Kang for helpful discussions, and Shuangni Yang for her help with the experiments on human skin. We thank the Skin Tissue Engineering Core Facility in Feinberg school of Medicine at Northwestern University for providing us with human skin tissues. This work was supported by the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program under Award No. W81XWH-16-1-0375. E.V.E. acknowledges support from the National Science Foundation Graduate Research Fellowship Program (DGE-1324585).

Keywords

Plasmonic microneedle arrays
SERS
agar gel skin phantom
human skin
pH in situ sensing

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/acs.nanolett.9b02070

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title = "Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS)",

abstract = "Surface-enhanced Raman spectroscopy (SERS) is a sensitive, chemically specific, and short-time response probing method with significant potential in biomedical sensing. This paper reports the integration of SERS with microneedle arrays as a minimally invasive platform for chemical sensing, with a particular view toward sensing in interstitial fluid (ISF). Microneedle arrays were fabricated from a commercial polymeric adhesive and coated with plasmonically active gold nanorods that were functionalized with the pH-sensitive molecule 4-mercaptobenzoic acid. This sensor can quantitate pH over a range of 5 to 9 and can detect pH levels in an agar gel skin phantom and in human skin in situ. The sensor array is stable and mechanically robust in that it exhibits no loss in SERS activity after multiple punches through an agar gel skin phantom and human skin or after a month-long incubation in phosphate-buffered saline. This work is the first to integrate SERS-active nanoparticles with polymeric microneedle arrays and to demonstrate in situ sensing with this platform.",

keywords = "Plasmonic microneedle arrays, SERS, agar gel skin phantom, human skin, pH in situ sensing",

author = "Park, {Ji Eun} and Nihan Yonet-Tanyeri and {Vander Ende}, Emma and Baruch, {Anne-Isabelle Henry} and {Perez White}, {Bethany E.} and Milan Mrksich and {Van Duyne}, {Richard P}",

note = "Funding Information: The authors thank Ian Rubinoff and Pengxiao Hao with their support with OCT, Tirzah Abbott with her help with SEM, Eric J. Berns, Vitor Brasiliense, and Gyeongwon Kang for helpful discussions, and Shuangni Yang for her help with the experiments on human skin. We thank the Skin Tissue Engineering Core Facility in Feinberg school of Medicine at Northwestern University for providing us with human skin tissues. This work was supported by the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program under Award No. W81XWH-16-1-0375. E.V.E. acknowledges support from the National Science Foundation Graduate Research Fellowship Program (DGE-1324585). Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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doi = "10.1021/acs.nanolett.9b02070",

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AU - Yonet-Tanyeri, Nihan

AU - Vander Ende, Emma

AU - Baruch, Anne-Isabelle Henry

AU - Perez White, Bethany E.

AU - Mrksich, Milan

AU - Van Duyne, Richard P

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PY - 2019/10/9

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N2 - Surface-enhanced Raman spectroscopy (SERS) is a sensitive, chemically specific, and short-time response probing method with significant potential in biomedical sensing. This paper reports the integration of SERS with microneedle arrays as a minimally invasive platform for chemical sensing, with a particular view toward sensing in interstitial fluid (ISF). Microneedle arrays were fabricated from a commercial polymeric adhesive and coated with plasmonically active gold nanorods that were functionalized with the pH-sensitive molecule 4-mercaptobenzoic acid. This sensor can quantitate pH over a range of 5 to 9 and can detect pH levels in an agar gel skin phantom and in human skin in situ. The sensor array is stable and mechanically robust in that it exhibits no loss in SERS activity after multiple punches through an agar gel skin phantom and human skin or after a month-long incubation in phosphate-buffered saline. This work is the first to integrate SERS-active nanoparticles with polymeric microneedle arrays and to demonstrate in situ sensing with this platform.

AB - Surface-enhanced Raman spectroscopy (SERS) is a sensitive, chemically specific, and short-time response probing method with significant potential in biomedical sensing. This paper reports the integration of SERS with microneedle arrays as a minimally invasive platform for chemical sensing, with a particular view toward sensing in interstitial fluid (ISF). Microneedle arrays were fabricated from a commercial polymeric adhesive and coated with plasmonically active gold nanorods that were functionalized with the pH-sensitive molecule 4-mercaptobenzoic acid. This sensor can quantitate pH over a range of 5 to 9 and can detect pH levels in an agar gel skin phantom and in human skin in situ. The sensor array is stable and mechanically robust in that it exhibits no loss in SERS activity after multiple punches through an agar gel skin phantom and human skin or after a month-long incubation in phosphate-buffered saline. This work is the first to integrate SERS-active nanoparticles with polymeric microneedle arrays and to demonstrate in situ sensing with this platform.

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Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS)

Abstract

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Keywords

ASJC Scopus subject areas

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