Plasticity of neuronal receptors

W. L. Klein, J. Sullivan, A. Skorupa, J. S. Aguilar

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

This article describes ways in which receptors, key components of signal propagation through a synapse, can mediate changes in that propagation. Changes occur at four levels: in the signal-transducing capability of a single receptor molecule, in the number of receptors per cell, in the subcellular placement of receptor molecules, and in the cytoarchitecture of receptor-rich regions. The ability of receptors to shift between different desired states is called plasticity, and such shifts can be long-lived as well as transient. In this article we focus on neuronal receptors, although key findings from a variety of cell systems are reported. Neuronal receptor plasticity may have a special role in the assembly as well as the adaptability of the nervous system.

Original languageEnglish (US)
Pages (from-to)2132-2140
Number of pages9
JournalFASEB Journal
Volume3
Issue number10
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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