Platelet 5-HT2 serotonin receptor binding sites in autistic children and their first-degree relatives

Bruce D. Perry*, Edwin H. Cook, Bennett L. Leventhal, Mark S. Wainwright, Daniel X. Freedman

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We examined platelet serotonin2 [5-hydroxytryptamine2 (5-HT2)] receptor binding sites, whole blood serotonin (5-HT), and plasma norepinephrine (NE) in male autistic children and their first-degree relatives. Saturation studies utilizing 125I-spiroperidol labeled the 5-HT2 sites with an affinity of 224.6 ± 84.4 pmol/L (Kd). No group differences, i.e., autistic (n = 12), siblings (n = 6), parents (n = 22), control (adult; n = 7: child; n = 10), were seen for either the Kd or the total number of sites (Bmax: 14.3 ± 10.9 fmol/mg protein). No correlations were found in any group between binding parameters (Kd or Bmax) and whole blood 5-HT. For the parental group, inverse correlations were found between NE and Bmax standing NE,rs = - 0.67, n = 21, p = 0.001; supine NE, rs = - 0.49, n = 22, p = 0.021). In the autistic group, no correlation was seen between plasma NE and Bmax. A correlation between the autistic boys' Bmax and their fathers' Bmax was observed (rs = 0.79, n = 11, p = 0.004). These findings suggest 1. (1) circulating NE may be involved in heterologous regulation of 5-HT2 receptors in the platelet and 2. (2) genetic (paternal-filial) factors may play a role in the expression of 5-HT2 binding sites in the platelet. These preliminary findings are discussed in relation to heterologous receptors regulation. The relationships between these findings and either the pathophysiology of autism or hyperserotonemia in autism are unknown.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalBiological psychiatry
Volume30
Issue number2
DOIs
StatePublished - Jul 15 1991

ASJC Scopus subject areas

  • Biological Psychiatry

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