Abstract
Background: Malignant peripheral nerve sheath tumor (MPNST) cells overexpress PDGF receptor-β, which increases intracellular calcium when activated. Results: Calcium/calmodulin (CaM) is involved in sustained phosphorylation of Akt and promotion of cell survival in an MPNST cell line. Conclusion: MPNST cells evade normal cell death through CaM-dependent sustained activation of Akt. Significance: Activation of CaM by abnormally expressed growth factor receptors may contribute to NF1 tumor formation.
Original language | English (US) |
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Pages (from-to) | 11066-11073 |
Number of pages | 8 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 16 |
DOIs | |
State | Published - Apr 19 2013 |
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Cell Biology