Platelet-derived growth factor receptor alpha in Glioma: A bed seed

Kun Wei Liu, Bo Hu*, Shi Yuan Cheng

*Corresponding author for this work

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Recent collaborative, large-sc ale genomic profiling of the most common and aggressive brain tumor glioblastoma multiforme (GBM) has significantly advanced our understanding of this disease. The gene encoding platelet-de rived growth factor receptor alpha (PDGFRα) was identified as the third of the top 11 amplified genes in clinical GBM specimens. The important roles of PDGFRα signaling during normal brain development also implicate the possible pathologic consequences of PDGFRα over-activation in glioma. Although the initial clinical trials using PDGFR kinase inhibitors have been predominantly disappointing, diagnostic and treatment modalities involving genomic profiling and personalized medicine are expected to improve the therapy targeting PDGFRα signaling. In this review, we discuss the roles of PDGFRα signaling during development of the normal central nervous system (CNS) and in pathologic conditions such as malignant glioma. We further compare various animal models of PDGF-in duced gliomagenesis and their potential as a novel platform of pre-clinical drug testing. We then summarize our recent publication and how these findings will likely impact treatments for gliomas driven by PDGFRα overexpression. A better understanding of PDGFRα signaling in glioma and their microenvironment, through the use of human or mouse models, is necessary to design a more effective therapeutic strategy against gliomas harboring the aberrant PDGFRα signaling.

Original languageEnglish (US)
Pages (from-to)590-602
Number of pages13
JournalChinese Journal of Cancer
Volume30
Issue number9
DOIs
StatePublished - Sep 27 2011

Keywords

  • Glioma tumorigenesis
  • Gliomas
  • Pdgfrα
  • Signaling

ASJC Scopus subject areas

  • Oncology

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