Platelet-derived growth factor signaling in human malignancies

Kun Wei Liu, Bo Hu*, Shi Yuan Cheng

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

13 Scopus citations


Platelet-derived growth factors (PDGFs) and their receptors were identified and purified decades ago. PDGFs are important during normal development and in human cancers. In particular, autocrine PDGF signaling has been implicated in various types of malignancies such as gliomas and leukemia. In contrast, paracrine signaling was found in cancers that originate from epithelial cells, where it may be involved in stromal cell recruitment, metastasis, and epithelial-m esenchymal transition. This editorial briefly discusses autocrine and paracrine PDGF signaling and their roles in human cancers, and introduces a series of review articles in this issue that address the possible roles of PDGFs in various processes involved in different types of cancers.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalChinese Journal of Cancer
Issue number9
StatePublished - 2011


  • Cancer
  • Drug resistance
  • Platelet-derived growth factor
  • Tumor progression

ASJC Scopus subject areas

  • Oncology


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