TY - JOUR
T1 - Platelet-derived growth factors and their receptors
T2 - Structural and functional perspectives
AU - Chen, Po Han
AU - Chen, Xiaoyan
AU - He, Xiaolin
N1 - Funding Information:
The authors wish to thank Heli Liu and Ann Shim for comments and help in the preparation of some figures. This work in the authors’ laboratory is supported by the NIH grant 5R01GM098259 .
PY - 2013
Y1 - 2013
N2 - The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important functions in the development of connective tissue cells. Recent structural studies have revealed novel mechanisms of PDGFs in propeptide loading and receptor recognition/activation. The detailed structural understanding of PDGF-PDGFR signaling has provided a template that can aid therapeutic intervention to counteract the aberrant signaling of this normally silent pathway, especially in proliferative diseases such as cancer. This review summarizes the advances in the PDGF system with a focus on relating the structural and functional understandings, and discusses the basic aspects of PDGFs and PDGFRs, the mechanisms of activation, and the insights into the therapeutic antagonism of PDGFRs. This article is part of a Special Issue entitled: Emerging recognition and activation mechanisms of receptor tyrosine kinases.
AB - The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important functions in the development of connective tissue cells. Recent structural studies have revealed novel mechanisms of PDGFs in propeptide loading and receptor recognition/activation. The detailed structural understanding of PDGF-PDGFR signaling has provided a template that can aid therapeutic intervention to counteract the aberrant signaling of this normally silent pathway, especially in proliferative diseases such as cancer. This review summarizes the advances in the PDGF system with a focus on relating the structural and functional understandings, and discusses the basic aspects of PDGFs and PDGFRs, the mechanisms of activation, and the insights into the therapeutic antagonism of PDGFRs. This article is part of a Special Issue entitled: Emerging recognition and activation mechanisms of receptor tyrosine kinases.
KW - Growth factor
KW - Propeptide recognition
KW - Receptor activation
KW - Receptor tyrosine kinase
KW - Signal transduction
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U2 - 10.1016/j.bbapap.2012.10.015
DO - 10.1016/j.bbapap.2012.10.015
M3 - Review article
C2 - 23137658
AN - SCOPUS:84884503107
VL - 1834
SP - 2176
EP - 2186
JO - BBA - Protein Structure
JF - BBA - Protein Structure
SN - 1570-9639
IS - 10
ER -
