Platelet Imipramine Binding in Depressed Children and Adolescents

Paul J. Ambrosini, Claudia Metz, Ramesh C. Arora, Jar Chi Lee, Lisa Kregel, Herbert Y. Meltzer

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Kinetic constants of platelet imipramine binding were determined in youths with major depression and a contrast group. Subjects actively depressed (N = 10) had significantly fewer imipramine binding sites (Bmax) (877 ± 148 fmol/mg protein) than recovering depressives (N = 12) (1220 ± 428 fmol/mg protein) and contrasts (N = 10) (1270 ± 230 fmol/mg protein). Affinity constants (Kd) (1.14 ± 0.36 nM, 0.97 ± 0.31 nM, and 1.17 ± 0.39 nM, respectively) were similar among the groups. Actively depressed males but not females had fewer imipramine binding sites than both their sex-matched comparison groups. Although actively depressed females' Bmax was significantly lower than recovering depressed and nondepressed males, neither age, Tannner stage, nor circannual rhythms influenced Bmax, but suicidality may be associated with low Bmax. A decrease in Bmax may be a state-specific marker of major depression in boys or associated with a depressive disorder with a suicidal history.

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume31
Issue number2
DOIs
StatePublished - Jan 1 1992

Keywords

  • depression
  • imipramine binding
  • suicidality

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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