Platelet monoamine oxidase activity and substrate preferences in schizophrenic patients

H. Y. Meltzer, S. M. Stahl

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69 Scopus citations

Abstract

Blood platelet monoamine oxidase (MAO) activity was measured in 12 chronic schizophrenic (CS) and 10 acute schizophrenic (AS) patients, and in 15 normal controls using 4 substrates. Platelet MAO activity of the CS patients was significantly lower than that of the controls with all 4 substrates. With the AS patients, platelet MAO activity was lower than that of the controls only with meta iodobenzylamine (MIB) or tyramine as substrates. Octopamine tended to be the best substrate for both patient groups and the lowest (together with tryptamine) for the control groups. MIB was the best substrate for the control group but the least active for the patients. Tyramine was the best substrate in distinguishing the schizophrenic patients and controls. Variations in the affinities of MAO for the multiple substrates suggest that the platelet MAO of AS and CS patients, and controls may contain different forms of MAO. Caution is urged in extrapolating the results from platelets to brain MAO and possible abnormalities of bioamine metabolism in schizophrenia.

Original languageEnglish (US)
Pages (from-to)419-431
Number of pages13
JournalRES.COMMUN.CHEM.PATH.PHARMACOL.
Volume7
Issue number2
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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