Platelet monoamine oxidase and plasma amine oxidase in psychiatric patients

H. Y. Meltzer, R. C. Arora, H. Jackman, G. Pscheidt, M. D. Smith

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Platelet monoamine oxidase (MAO) and plasma amino oxidase (PAO) activities were determined in 70 normal controls and 76 psychiatric patients. Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a strong trend for chronic schizophrenics to have lower MAO activity. Schizophrenic patients with Schneiderian-type hallucinations had significantly lower MAO activity than normal controls or schizophrenic patients who did not hallucinate. There was no relationship between hallucinations and platelet MAO activity in patients with affective psychoses. Paranoid shizophrenics did not have significantly different MAO activity from nonparanoid schizophrenics. PAO activity was generally lower in all diagnostic groups than in normal controls, but the results were statistically significant only for acute schizophrenics.

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalSchizophrenia bulletin
Volume6
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Psychiatry and Mental health

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