Platelet-rich plasma in orthopaedic applications: Evidence-based recommendations for treatment

Wellington K. Hsu*, Allan Mishra, Scott R. Rodeo, Freddie Fu, Michael A. Terry, Pietro Randelli, S. Terry Canale, Frank B. Kelly

*Corresponding author for this work

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

Autologous platelet-rich plasma (PRP) therapies have seen a dramatic increase in breadth and frequency of use for orthopaedic conditions in the past 5 years. Rich in many growth factors that have important implications in healing, PRP can potentially regenerate tissue via multiple mechanisms. Proposed clinical and surgical applications include spinal fusion, chondropathy, knee osteoarthritis, tendinopathy, acute and chronic soft-tissue injuries, enhancement of healing after ligament reconstruction, and muscle strains. However, for many conditions, there is limited reliable clinical evidence to guide the use of PRP. Furthermore, classification systems and identification of differences among products are needed to understand the implications of variability.

Original languageEnglish (US)
Pages (from-to)739-748
Number of pages10
JournalJournal of the American Academy of Orthopaedic Surgeons
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2012

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ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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