Platelet serotonergic markers and tridimensional personality questionnaire measures in a clinical sample

Elliot C. Nelson*, C. Robert Cloninger, Thomas R. Przybeck, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A group of patients with major depressive disorder, with and without comorbid obsessive compulsive disorder, completed the Tridimensional Personality Questionnaire (TPQ). Harm Avoidance scores were found to be high compared to published age-matched norms and to display a significant positive correlation with Hamilton Depression Rating Scale scores. Platelet 125I-lysergic acid diethylamide (125I-LSD) and 3H-paroxetine binding B(max) values were measured to test Cloninger's hypothesis that Harm Avoidance scores would correlate significantly with measures of serotonergic function. A significant inverse correlation was found between Harm Avoidance scores and 125I-LSD B(max) values. Correlations between 3H-paroxetine B(max) values and TPQ scale scores were not significant. These results suggest an alternative view of the literature relating platelet 5-hydroxytryptamine-2a receptors and mood disorders in that the temperament dimension, Harm Avoidance, may explain prior inconsistencies involving links with depression and suicidality.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalBiological psychiatry
Issue number4
StatePublished - Aug 15 1996


  • Biological markers
  • Major depressive disorder
  • Obsessive-compulsive disorder
  • Paroxetine binding
  • Personality inventories
  • Serotonin

ASJC Scopus subject areas

  • Biological Psychiatry

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