Platelet‐activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis

W. Hsueh*, MS Caplan, X. Sun, Xiaodi Tan, W. MacKendrick, F. Gonzalez‐Crussi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood. We have established several animal models of NEC by using a combination of various stimuli and stress, including endotoxin, PAF, TNF, and hypoxia. We discuss the mechanism of their actions and the possible roles of these factors in the pathogenesis of human NEC.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalActa Pædiatrica
Volume83
DOIs
StatePublished - Jan 1 1994

Keywords

  • Hypoxia
  • necrotizing enterocolitis
  • platelet activating factor
  • tumor necrosis factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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