Platelet‐activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis

W. Hsueh*, MS Caplan, X. Sun, X. Tan, W. MacKendrick, F. Gonzalez‐Crussi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood. We have established several animal models of NEC by using a combination of various stimuli and stress, including endotoxin, PAF, TNF, and hypoxia. We discuss the mechanism of their actions and the possible roles of these factors in the pathogenesis of human NEC.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalActa Pædiatrica
StatePublished - Apr 1994


  • Hypoxia
  • necrotizing enterocolitis
  • platelet activating factor
  • tumor necrosis factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Platelet‐activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis'. Together they form a unique fingerprint.

Cite this