Plexiform fibromyxoma with cotyledon‑like serosal growth: A case report of a rare gastric tumor and review of the literature

Joshua Robert Kane, Natasha Lewis, Rebecca Lin, Celina Villa, Alexandra Larson, Jeffrey D. Wayne, Anjana V. Yeldandi, William B. Laskin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Plexiform fibromyxoma is a rare, benign mesenchymal neoplasm that predilects the gastric antrum and has potential for misdiagnosis as a gastrointestinal stromal tumor (GIST). The histology of the tumor is characterized by interwoven fascicular growth of cytologically bland spindled cells within a variably myxoid stroma. The current study reports the clinicopathological and immunohistochemical findings of a plexiform fibromyxoma resected from a 28‑year‑old Vietnamese female. The patient presented with acute, severe abdominal pain and worsening anemia. The initial fine‑needle aspiration and needle core biopsy of the gastric antral mass led to an initial diagnosis of GIST. The subsequent distal partial gastrectomy revealed a 5.5‑cm transmural antral mass that ulcerated the overlying mucosa and grew as variably elongated, myxoedematous, polypoid (cotyledon‑like) excrescences from the serosal surface. Microscopically, the tumor demonstrated plexiform and multinodular growth of cytologically bland spindled cells proliferating in an abundant myxocollagenous stroma with a prominent capillary network. Tumor cells immunohistochemically expressed smooth muscle actin and CD10, but did not express CD117, Discovered on GIST‑1 or nuclear β‑catenin. Follow‑up evaluation 23 months post surgery revealed no evidence of residual tumor. A review the cases of this rare entity reported in the English language literature is also provided.

Original languageEnglish (US)
Pages (from-to)2189-2194
Number of pages6
JournalOncology Letters
Issue number3
StatePublished - Mar 2016


  • Cotyledon‑like growth
  • Gastrointestinal stromal tumor
  • Immunohistochemistry
  • Plexiform fibromyxoma
  • Stomach

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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