PMN chemotactic inhibition associated with a cryoglobulin

A. Todd Davis*, Pamela G. Grady, Emmanuel Shapira, Lauren M. Pachman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A child with recurrent pyogenic infections, eczema, markedly elevated serum concentrations of IgA, and totally absent PMN chemotactic activity is described. The chemotactic defect was characterized as a humoral inhibitor present in serum and plasma, directed toward autologous as well as homologous PMN's. Immunochemical studies revealed the purified inhibitor to be a cryoglobulin composed of an IgM-IgA complex. Incubation of the cryoglobulin complex with PMN's resulted in a quantitative dose-response curve.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalThe Journal of pediatrics
Issue number2
StatePublished - Feb 1977

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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