PMN chemotactic inhibition associated with a cryoglobulin

A. Todd Davis; Pamela G. Grady; Emmanuel Shapira; Lauren M. Pachman

doi:10.1016/S0022-3476(77)80634-3

PMN chemotactic inhibition associated with a cryoglobulin

A. Todd Davis^*, Pamela G. Grady, Emmanuel Shapira, Lauren M. Pachman

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A child with recurrent pyogenic infections, eczema, markedly elevated serum concentrations of IgA, and totally absent PMN chemotactic activity is described. The chemotactic defect was characterized as a humoral inhibitor present in serum and plasma, directed toward autologous as well as homologous PMN's. Immunochemical studies revealed the purified inhibitor to be a cryoglobulin composed of an IgM-IgA complex. Incubation of the cryoglobulin complex with PMN's resulted in a quantitative dose-response curve.

Original language	English (US)
Pages (from-to)	225-229
Number of pages	5
Journal	The Journal of pediatrics
Volume	90
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(77)80634-3
State	Published - Feb 1977

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(77)80634-3

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title = "PMN chemotactic inhibition associated with a cryoglobulin",

abstract = "A child with recurrent pyogenic infections, eczema, markedly elevated serum concentrations of IgA, and totally absent PMN chemotactic activity is described. The chemotactic defect was characterized as a humoral inhibitor present in serum and plasma, directed toward autologous as well as homologous PMN's. Immunochemical studies revealed the purified inhibitor to be a cryoglobulin composed of an IgM-IgA complex. Incubation of the cryoglobulin complex with PMN's resulted in a quantitative dose-response curve.",

author = "Davis, {A. Todd} and Grady, {Pamela G.} and Emmanuel Shapira and Pachman, {Lauren M.}",

note = "Funding Information: From the Divisions of Infectious Disease, Immunology, and Genetics, The Children's Memorial Hospital. Supported by National Institutes of Health Grants MO1-RRO0199 and 5S01RR05475-12, and by the Notz Family Fund. Presented in part at the annual meeting of the American Pediatric Society-Society for Pediatric Research, April 18, 1975, Denver, CO. *Reprint address: Division of Infectious Disease, The Children's Memorial Hospital, Chicago, IL 60614.",

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doi = "10.1016/S0022-3476(77)80634-3",

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T1 - PMN chemotactic inhibition associated with a cryoglobulin

AU - Davis, A. Todd

AU - Grady, Pamela G.

AU - Shapira, Emmanuel

AU - Pachman, Lauren M.

N1 - Funding Information: From the Divisions of Infectious Disease, Immunology, and Genetics, The Children's Memorial Hospital. Supported by National Institutes of Health Grants MO1-RRO0199 and 5S01RR05475-12, and by the Notz Family Fund. Presented in part at the annual meeting of the American Pediatric Society-Society for Pediatric Research, April 18, 1975, Denver, CO. *Reprint address: Division of Infectious Disease, The Children's Memorial Hospital, Chicago, IL 60614.

PY - 1977/2

Y1 - 1977/2

N2 - A child with recurrent pyogenic infections, eczema, markedly elevated serum concentrations of IgA, and totally absent PMN chemotactic activity is described. The chemotactic defect was characterized as a humoral inhibitor present in serum and plasma, directed toward autologous as well as homologous PMN's. Immunochemical studies revealed the purified inhibitor to be a cryoglobulin composed of an IgM-IgA complex. Incubation of the cryoglobulin complex with PMN's resulted in a quantitative dose-response curve.

AB - A child with recurrent pyogenic infections, eczema, markedly elevated serum concentrations of IgA, and totally absent PMN chemotactic activity is described. The chemotactic defect was characterized as a humoral inhibitor present in serum and plasma, directed toward autologous as well as homologous PMN's. Immunochemical studies revealed the purified inhibitor to be a cryoglobulin composed of an IgM-IgA complex. Incubation of the cryoglobulin complex with PMN's resulted in a quantitative dose-response curve.

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PMN chemotactic inhibition associated with a cryoglobulin

Abstract

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