Pneumococcal endocarditis in children

Laurence B. Givner*, Edward O. Mason, Tina Q. Tan, William J. Barson, Gordon E. Schutze, Ellen R. Wald, John S. Bradley, Jill Hoffman, Ram Yogev, Sheldon L. Kaplan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Endocarditis due to Streptococcus pneumoniae is unusual in children, accounting for 3%-7% of all cases of childhood endocarditis. The US Pediatric Multicenter Pneumococcal Surveillance Group has prospectively identified patients with invasive disease at 8 children's hospitals. During the period of 1 September 1993 through 28 February 2003, a total of 11 children with pneumococcal endocarditis were seen. Seven (64%) were 3-36 months old; 8 (73%) were boys. Ten (91%) had preexisting structural heart disease; 5 had undergone previous heart surgery. Concomitant sites of infection were noted in 6 patients (55%), including 3 patients with meningitis. One patient (9%) died during hospitalization, and 5 others (45%) experienced serious complications. Only 2 patients remained hospitalized for their entire course of parenteral antibiotic therapy. Eight of 10 pneumococcal isolates tested were vaccine or vaccine-related serotypes included in the currently licensed 7-valent conjugated pneumococcal vaccine. Pneumococcal endocarditis in children is unusual but often has serious complications.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalClinical Infectious Diseases
Issue number9
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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