Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia

Raul E. Isturiz, Julio Ramirez, Wesley H. Self, Carlos G. Grijalva, Francis L. Counselman, Gregory Volturo, Luis Ostrosky-Zeichner, Paula Peyrani, Richard G Wunderink, Robert Sherwin, J. Scott Overcash, Senen Pena Oliva, Thomas File, Timothy L. Wiemken, John M. McLaughlin, Michael W. Pride, Sharon Gray, Ronika Alexander, Kimbal D. Ford, Qin Jiang & 1 others Luis Jodar

Research output: Contribution to journalArticle

Abstract

Background: Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13)into the US infant vaccination schedule. Further, most data regarding pneumococcal serotypes are derived from invasive pneumococcal disease (IPD), which represents only a fraction of all adult pneumococcal disease burden. Understanding which pneumococcal serotypes cause pneumonia in adults is critical for informing current immunization policy. The objective of this study was to measure the proportion of radiographically-confirmed (CXR+)community-acquired pneumonia (CAP)caused by PCV13 serotypes in hospitalized US adults. Methods: This observational, prospective surveillance study recruited hospitalized adults aged ≥18 years from 21 acute care hospitals across 10 geographically-dispersed cities in the United States between October 2013 and September 2016. Clinical and demographic data were collected during hospitalization. Vital status was ascertained 30 days after enrollment. Pneumococcal serotypes were detected via culture from the respiratory tract and normally-sterile sites (including blood and pleural fluid). Additionally, a novel, Luminex-based serotype-specific urinary antigen detection (UAD)assay was used to detect serotypes included in PCV13. Results: Of 15,572 enrolled participants, 12,055 eligible patients with CXR+CAP were included in the final analysis population. Mean age was 64.1 years and 52.7% were aged ≥65 years. Common comorbidities included chronic obstructive pulmonary disease (43.0%)and diabetes mellitus (28.6%). PCV13 serotypes were detected in 552/12,055 (4.6%)of all patients and 265/6347 (4.2%)of those aged ≥65 years. Among patients aged 18–64 years PCV13 serotypes were detected in 3.8–5.3% of patients depending on their risk status. Conclusions: After implementation of a pneumococcal conjugate vaccination program in US children, and despite the herd protection observed in US adults, a persistent burden of PCV13-type CAP remains in this population.

Original languageEnglish (US)
Pages (from-to)3352-3361
Number of pages10
JournalVaccine
Volume37
Issue number25
DOIs
StatePublished - May 31 2019

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pneumonia
epidemiology
Pneumonia
serotypes
Epidemiology
Vaccination
vaccination
Conjugate Vaccines
antigen detection
burden of disease
Serogroup
diabetes mellitus
respiratory system
Respiratory System
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
Population
Comorbidity
Immunization
Diabetes Mellitus

Keywords

  • Community
  • Pneumococcus
  • Pneumonia
  • Streptococcus

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Isturiz, R. E., Ramirez, J., Self, W. H., Grijalva, C. G., Counselman, F. L., Volturo, G., ... Jodar, L. (2019). Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia. Vaccine, 37(25), 3352-3361. https://doi.org/10.1016/j.vaccine.2019.04.087
Isturiz, Raul E. ; Ramirez, Julio ; Self, Wesley H. ; Grijalva, Carlos G. ; Counselman, Francis L. ; Volturo, Gregory ; Ostrosky-Zeichner, Luis ; Peyrani, Paula ; Wunderink, Richard G ; Sherwin, Robert ; Overcash, J. Scott ; Oliva, Senen Pena ; File, Thomas ; Wiemken, Timothy L. ; McLaughlin, John M. ; Pride, Michael W. ; Gray, Sharon ; Alexander, Ronika ; Ford, Kimbal D. ; Jiang, Qin ; Jodar, Luis. / Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia. In: Vaccine. 2019 ; Vol. 37, No. 25. pp. 3352-3361.
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abstract = "Background: Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13)into the US infant vaccination schedule. Further, most data regarding pneumococcal serotypes are derived from invasive pneumococcal disease (IPD), which represents only a fraction of all adult pneumococcal disease burden. Understanding which pneumococcal serotypes cause pneumonia in adults is critical for informing current immunization policy. The objective of this study was to measure the proportion of radiographically-confirmed (CXR+)community-acquired pneumonia (CAP)caused by PCV13 serotypes in hospitalized US adults. Methods: This observational, prospective surveillance study recruited hospitalized adults aged ≥18 years from 21 acute care hospitals across 10 geographically-dispersed cities in the United States between October 2013 and September 2016. Clinical and demographic data were collected during hospitalization. Vital status was ascertained 30 days after enrollment. Pneumococcal serotypes were detected via culture from the respiratory tract and normally-sterile sites (including blood and pleural fluid). Additionally, a novel, Luminex-based serotype-specific urinary antigen detection (UAD)assay was used to detect serotypes included in PCV13. Results: Of 15,572 enrolled participants, 12,055 eligible patients with CXR+CAP were included in the final analysis population. Mean age was 64.1 years and 52.7{\%} were aged ≥65 years. Common comorbidities included chronic obstructive pulmonary disease (43.0{\%})and diabetes mellitus (28.6{\%}). PCV13 serotypes were detected in 552/12,055 (4.6{\%})of all patients and 265/6347 (4.2{\%})of those aged ≥65 years. Among patients aged 18–64 years PCV13 serotypes were detected in 3.8–5.3{\%} of patients depending on their risk status. Conclusions: After implementation of a pneumococcal conjugate vaccination program in US children, and despite the herd protection observed in US adults, a persistent burden of PCV13-type CAP remains in this population.",
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Isturiz, RE, Ramirez, J, Self, WH, Grijalva, CG, Counselman, FL, Volturo, G, Ostrosky-Zeichner, L, Peyrani, P, Wunderink, RG, Sherwin, R, Overcash, JS, Oliva, SP, File, T, Wiemken, TL, McLaughlin, JM, Pride, MW, Gray, S, Alexander, R, Ford, KD, Jiang, Q & Jodar, L 2019, 'Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia', Vaccine, vol. 37, no. 25, pp. 3352-3361. https://doi.org/10.1016/j.vaccine.2019.04.087

Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia. / Isturiz, Raul E.; Ramirez, Julio; Self, Wesley H.; Grijalva, Carlos G.; Counselman, Francis L.; Volturo, Gregory; Ostrosky-Zeichner, Luis; Peyrani, Paula; Wunderink, Richard G; Sherwin, Robert; Overcash, J. Scott; Oliva, Senen Pena; File, Thomas; Wiemken, Timothy L.; McLaughlin, John M.; Pride, Michael W.; Gray, Sharon; Alexander, Ronika; Ford, Kimbal D.; Jiang, Qin; Jodar, Luis.

In: Vaccine, Vol. 37, No. 25, 31.05.2019, p. 3352-3361.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia

AU - Isturiz, Raul E.

AU - Ramirez, Julio

AU - Self, Wesley H.

AU - Grijalva, Carlos G.

AU - Counselman, Francis L.

AU - Volturo, Gregory

AU - Ostrosky-Zeichner, Luis

AU - Peyrani, Paula

AU - Wunderink, Richard G

AU - Sherwin, Robert

AU - Overcash, J. Scott

AU - Oliva, Senen Pena

AU - File, Thomas

AU - Wiemken, Timothy L.

AU - McLaughlin, John M.

AU - Pride, Michael W.

AU - Gray, Sharon

AU - Alexander, Ronika

AU - Ford, Kimbal D.

AU - Jiang, Qin

AU - Jodar, Luis

PY - 2019/5/31

Y1 - 2019/5/31

N2 - Background: Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13)into the US infant vaccination schedule. Further, most data regarding pneumococcal serotypes are derived from invasive pneumococcal disease (IPD), which represents only a fraction of all adult pneumococcal disease burden. Understanding which pneumococcal serotypes cause pneumonia in adults is critical for informing current immunization policy. The objective of this study was to measure the proportion of radiographically-confirmed (CXR+)community-acquired pneumonia (CAP)caused by PCV13 serotypes in hospitalized US adults. Methods: This observational, prospective surveillance study recruited hospitalized adults aged ≥18 years from 21 acute care hospitals across 10 geographically-dispersed cities in the United States between October 2013 and September 2016. Clinical and demographic data were collected during hospitalization. Vital status was ascertained 30 days after enrollment. Pneumococcal serotypes were detected via culture from the respiratory tract and normally-sterile sites (including blood and pleural fluid). Additionally, a novel, Luminex-based serotype-specific urinary antigen detection (UAD)assay was used to detect serotypes included in PCV13. Results: Of 15,572 enrolled participants, 12,055 eligible patients with CXR+CAP were included in the final analysis population. Mean age was 64.1 years and 52.7% were aged ≥65 years. Common comorbidities included chronic obstructive pulmonary disease (43.0%)and diabetes mellitus (28.6%). PCV13 serotypes were detected in 552/12,055 (4.6%)of all patients and 265/6347 (4.2%)of those aged ≥65 years. Among patients aged 18–64 years PCV13 serotypes were detected in 3.8–5.3% of patients depending on their risk status. Conclusions: After implementation of a pneumococcal conjugate vaccination program in US children, and despite the herd protection observed in US adults, a persistent burden of PCV13-type CAP remains in this population.

AB - Background: Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13)into the US infant vaccination schedule. Further, most data regarding pneumococcal serotypes are derived from invasive pneumococcal disease (IPD), which represents only a fraction of all adult pneumococcal disease burden. Understanding which pneumococcal serotypes cause pneumonia in adults is critical for informing current immunization policy. The objective of this study was to measure the proportion of radiographically-confirmed (CXR+)community-acquired pneumonia (CAP)caused by PCV13 serotypes in hospitalized US adults. Methods: This observational, prospective surveillance study recruited hospitalized adults aged ≥18 years from 21 acute care hospitals across 10 geographically-dispersed cities in the United States between October 2013 and September 2016. Clinical and demographic data were collected during hospitalization. Vital status was ascertained 30 days after enrollment. Pneumococcal serotypes were detected via culture from the respiratory tract and normally-sterile sites (including blood and pleural fluid). Additionally, a novel, Luminex-based serotype-specific urinary antigen detection (UAD)assay was used to detect serotypes included in PCV13. Results: Of 15,572 enrolled participants, 12,055 eligible patients with CXR+CAP were included in the final analysis population. Mean age was 64.1 years and 52.7% were aged ≥65 years. Common comorbidities included chronic obstructive pulmonary disease (43.0%)and diabetes mellitus (28.6%). PCV13 serotypes were detected in 552/12,055 (4.6%)of all patients and 265/6347 (4.2%)of those aged ≥65 years. Among patients aged 18–64 years PCV13 serotypes were detected in 3.8–5.3% of patients depending on their risk status. Conclusions: After implementation of a pneumococcal conjugate vaccination program in US children, and despite the herd protection observed in US adults, a persistent burden of PCV13-type CAP remains in this population.

KW - Community

KW - Pneumococcus

KW - Pneumonia

KW - Streptococcus

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Isturiz RE, Ramirez J, Self WH, Grijalva CG, Counselman FL, Volturo G et al. Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia. Vaccine. 2019 May 31;37(25):3352-3361. https://doi.org/10.1016/j.vaccine.2019.04.087