Pneumocystis carinii Pneumonia during Cyclosporine Therapy for Ulcerative Colitis

M. B. Smith, S. B. Hanauer

Research output: Contribution to journalLetterpeer-review

47 Scopus citations


To the Editor: Cyclosporine has been used in patients with severe refractory inflammatory bowel disease1 , 2 without an increase in infectious complications.3 We report a case of Pneumocystis carinii pneumonia that occurred in a man with ulcerative colitis during treatment with cyclosporine. Fever, bloody diarrhea, and abdominal cramps developed in a 32-year-old man receiving maintenance therapy with mesalamine. His symptoms persisted despite seven days of intravenous hydrocortisone therapy. The patient rejected recommendations that he undergo colectomy. He was therefore treated with 4 mg of intravenous cyclosporine per kilogram of body weight per day, and the intravenous hydrocortisone (300 mg per day)…

Original languageEnglish (US)
Pages (from-to)497-498
Number of pages2
JournalNew England Journal of Medicine
Issue number7
StatePublished - Aug 13 1992

ASJC Scopus subject areas

  • Medicine(all)

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