Pneumonectomy for Pediatric Tumors - A Pediatric Surgical Oncology Research Collaborative Study

Stephanie F. Polites, Todd E. Heaton, Michael P. Laquaglia, Eugene S. Kim, Wesley E. Barry, Catherine J. Goodhue, Andrew J. Murphy, Andrew M. Davidoff, Max R. Langham, Rebecka L. Meyers, Scott S. Short, Timothy B. Lautz, Richard D. Glick, Sanjeev A. Vasudevan, Christina M. Bence, Dave R. Lal, Reto M. Baertschiger, Bryanna Emr, Marcus M. Malek, Roshni Dasgupta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective:To describe utilization and long-term outcomes of pneumonectomy in children and adolescents with cancer.Summary Background Data:Pneumonectomy in adults is associated with significant morbidity and mortality. Little is known about the indications and outcomes of pneumonectomy for pediatric tumors.Methods:The Pediatric Surgical Oncology Research Collaborative (PSORC) identified pediatric patients <21 years of age who underwent pneumonectomy from 1990 to 2017 for primary or metastatic tumors at 12 institutions. Clinical information was collected; outcomes included operative complications, long-term function, recurrence, and survival. Univariate log rank, and multivariable Cox analyses determined factors associated with survival.Results:Thirty-eight patients (mean 12 ± 6 yrs) were identified; median (IQR) follow-up was 19 (5-38) months. Twenty-six patients (68%) underwent pneumonectomy for primary tumors and 12 (32%) for metastases. The most frequent histologies were osteosarcoma (n = 6), inflammatory myofibroblastic tumors (IMT; n = 6), and pleuropulmonary blastoma (n = 5). Median postoperative ventilator days were 0 (0-1), intensive care 2 (1-3), and hospital 8 (5-16). Early postoperative complications occurred in 10 patients including 1 death. Of 25 (66%) patients alive at 1 year, 15 reported return to preoperative pulmonary status. All IMT patients survived while all osteosarcoma patients died during follow-up. On multivariable analysis, metastatic indications were associated with nonsurvival (HR = 3.37, P = 0.045)Conclusion:This is the largest review of children who underwent pneumonectomy for cancer. There is decreased procedure-related morbidity and mortality than reported for adults. Survival is worse with preoperative metastatic disease, especially osteosarcoma.

Original languageEnglish (US)
Pages (from-to)E605-E609
JournalAnnals of surgery
Volume274
Issue number6
DOIs
StatePublished - Dec 1 2021

Keywords

  • inflammatory myofibroblastic tumor
  • pediatric
  • pleuropulmonary blastoma
  • pneumonectomy
  • sarcoma
  • surgical oncology

ASJC Scopus subject areas

  • Surgery

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