Podosome rosettes precede vascular sprouts in tumour angiogenesis

Carmen M. Warren, M. Luisa Iruela-Arispe

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalNature Cell Biology
Issue number10
StatePublished - Oct 1 2014

ASJC Scopus subject areas

  • Cell Biology


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