Podosome rosettes precede vascular sprouts in tumour angiogenesis

Carmen M. Warren; M. Luisa Iruela-Arispe

doi:10.1038/ncb3044

Podosome rosettes precede vascular sprouts in tumour angiogenesis

Carmen M. Warren, M. Luisa Iruela-Arispe

Cell & Developmental Biology

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.

Original language	English (US)
Pages (from-to)	928-930
Number of pages	3
Journal	Nature Cell Biology
Volume	16
Issue number	10
DOIs	https://doi.org/10.1038/ncb3044
State	Published - Oct 1 2014

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncb3044

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title = "Podosome rosettes precede vascular sprouts in tumour angiogenesis",

abstract = "Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.",

author = "Warren, {Carmen M.} and Iruela-Arispe, {M. Luisa}",

year = "2014",

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T1 - Podosome rosettes precede vascular sprouts in tumour angiogenesis

AU - Warren, Carmen M.

AU - Iruela-Arispe, M. Luisa

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N2 - Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.

AB - Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.

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DO - 10.1038/ncb3044

M3 - Review article

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JO - Nature Cell Biology

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Podosome rosettes precede vascular sprouts in tumour angiogenesis

Abstract

ASJC Scopus subject areas

UN SDGs

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