Point-of-care testing to promote cardiovascular disease risk assessment: A proof of concept study

Kunal N. Karmali*, Tiffany Brown, Thomas Sanchez, Timothy Long, Stephen D. Persell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Updated cholesterol guidelines emphasize multivariable cardiovascular disease (CVD) risk estimation to guide treatment decision-making in primary prevention. This study tested the preliminary feasibility, acceptability and efficacy of point-of-care testing (POCT) and quantitative CVD risk assessment in high-risk adults to increase guideline-recommended statin use in primary prevention. Participants were aged 40–75 years, without CVD or diabetes mellitus, and potentially-eligible for consideration of statins based on estimated 10-year CVD risk from last-measured risk factor levels in the electronic health record. We performed POCT to facilitate quantitative CVD risk assessment with the Pooled Cohort Equations immediately before a scheduled primary care provider (PCP) visit. Outcomes were: physician documentation of a CVD risk discussion and statin prescription on the study date. We also assessed acceptability of the intervention through structured questionnaire. We recruited 18 participants (8 from an academic practice and 10 from a federally-qualified health clinic). After the intervention, 83% of participants discussed CVD risk with their PCP, 47% received a statin recommendation from their PCP, and 29% received a new statin prescription during the PCP visit. Participants reported high levels of satisfaction with the intervention. This study demonstrates that in initial testing pre-visit POCT and quantitative CVD risk assessment appears to be a feasible and acceptable intervention that may promote guideline-recommended statin initiation in primary prevention. Future research with an adequately powered trial is warranted to determine the effectiveness of this approach in clinical practice.

Original languageEnglish (US)
Pages (from-to)136-139
Number of pages4
JournalPreventive Medicine Reports
StatePublished - Sep 2017


  • Cardiovascular disease prevention
  • Point-of-care testing
  • Risk assessment

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Informatics


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