TY - JOUR
T1 - Polarization gating spectroscopy of normal-appearing duodenal mucosa to detect pancreatic cancer
AU - Patel, Mihir
AU - Gomes, Andrew
AU - Ruderman, Sarah
AU - Hardee, Darla
AU - Crespo, Sergio
AU - Raimondo, Massimo
AU - Woodward, Timothy
AU - Backman, Vadim
AU - Roy, Hemant
AU - Wallace, Michael
N1 - Publisher Copyright:
Copyright © 2014 by the American Society for Gastrointestinal Endoscopy.
PY - 2014
Y1 - 2014
N2 - Background: According to the field effect theory, by detecting microvasculature changes such as early increase in blood supply (EIBS) in the surrounding tissue, neoplastic lesions can be identified from a distance. Objective: To determine the feasibility and efficacy of a fiberoptic probe containing novel polarization gating spectroscopy technology to identify patients with pancreatic adenocarcinoma (PAC) by the field effect theory. Design: Prospective cohort (pilot) study. Setting: Outpatient tertiary care center. Patients: Adult (R18 years) patients undergoing EGD-EUS were screened. Patients with PAC were included in the "cancer" group and patients without PAC were included in the "control" group. We excluded patients with other known malignancies and gastroduodenal premalignant lesions. Interventions and Main Outcome Measures: Spectroscopic measurements of EIBS variables, such as deoxyhemoglobin concentration (DHb) and mean blood vessel radius (BVR), were obtained from 5 periampullary locations. The Mann-Whitney rank sum test was used for the statistical analysis (P % .05). Results: Fourteen patients (mean age 72 years, 79% male) in the cancer group and 15 patients (mean age 63 years, 60% male) in the control group were included in the final analysis. At the ampullary site, both DHb (P Z .001) and BVR (P Z .03) were higher in PAC patients than in the control subjects. The DHb alone (92% sensitivity, 86% specificity) or in combination with BVR (92% sensitivity, 79% specificity) can differentiate PAC from control subjects with high accuracy. Limitations: Small sample size, unmatched control subjects. Conclusions: Spectroscopic measurements of EIBS by fiberoptic probes are feasible. Preliminary evidence suggests that in vivo measurement of normal-appearing duodenal tissue can differentiate PAC patients from a distance with high accuracy.
AB - Background: According to the field effect theory, by detecting microvasculature changes such as early increase in blood supply (EIBS) in the surrounding tissue, neoplastic lesions can be identified from a distance. Objective: To determine the feasibility and efficacy of a fiberoptic probe containing novel polarization gating spectroscopy technology to identify patients with pancreatic adenocarcinoma (PAC) by the field effect theory. Design: Prospective cohort (pilot) study. Setting: Outpatient tertiary care center. Patients: Adult (R18 years) patients undergoing EGD-EUS were screened. Patients with PAC were included in the "cancer" group and patients without PAC were included in the "control" group. We excluded patients with other known malignancies and gastroduodenal premalignant lesions. Interventions and Main Outcome Measures: Spectroscopic measurements of EIBS variables, such as deoxyhemoglobin concentration (DHb) and mean blood vessel radius (BVR), were obtained from 5 periampullary locations. The Mann-Whitney rank sum test was used for the statistical analysis (P % .05). Results: Fourteen patients (mean age 72 years, 79% male) in the cancer group and 15 patients (mean age 63 years, 60% male) in the control group were included in the final analysis. At the ampullary site, both DHb (P Z .001) and BVR (P Z .03) were higher in PAC patients than in the control subjects. The DHb alone (92% sensitivity, 86% specificity) or in combination with BVR (92% sensitivity, 79% specificity) can differentiate PAC from control subjects with high accuracy. Limitations: Small sample size, unmatched control subjects. Conclusions: Spectroscopic measurements of EIBS by fiberoptic probes are feasible. Preliminary evidence suggests that in vivo measurement of normal-appearing duodenal tissue can differentiate PAC patients from a distance with high accuracy.
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U2 - 10.1016/j.gie.2014.03.031
DO - 10.1016/j.gie.2014.03.031
M3 - Article
C2 - 24861243
AN - SCOPUS:84927799574
SN - 0016-5107
VL - 80
SP - 786-793.e2
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
IS - 5
ER -