Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis

Young Kim, Yang Liu, Ramesh Wali, Hemant Roy, Michael Goldberg, Vladimir Turzhitsky, Vadim Backman*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We used polarization spectroscopy to investigated changes in subepithelial blood supply in the initial stages of colon carcinogenesis. We observed, for the first time, a profound early increase in subepithelial blood supply (EIBS) at a time point that precedes the development of adenomas as well as any other currently available markers of colon cancer. Although it has been previously established that later-stage lesions (e.g. at the adenoma-carcinoma stage) have increased blood supply, ours were the first data to show such early aberrations of blood supply in early predysplastic stages of colon carcinogenesis. Therefore, optically detectable EIBS may potentially be used for diagnosis of previously undetectable stages of colonic neoplasia and may provide further insights into the pathophysiology of the earliest stages of colon carcinogenesis.

Original languageEnglish (US)
Title of host publicationBiomedical Topical Meeting, BIOMED 2004
PublisherOptica Publishing Group (formerly OSA)
ISBN (Electronic)1557527695
StatePublished - 2004
EventBiomedical Topical Meeting, BIOMED 2004 - Miami Beach, United States
Duration: Apr 14 2004Apr 17 2004

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceBiomedical Topical Meeting, BIOMED 2004
Country/TerritoryUnited States
CityMiami Beach

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


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