Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis

Young Kim; Yang Liu; Ramesh Wali; Hemant Roy; Michael Goldberg; Vladimir Turzhitsky; Vadim Backman

Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis

Young Kim, Yang Liu, Ramesh Wali, Hemant Roy, Michael Goldberg, Vladimir Turzhitsky, Vadim Backman^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We used polarization spectroscopy to investigated changes in subepithelial blood supply in the initial stages of colon carcinogenesis. We observed, for the first time, a profound early increase in subepithelial blood supply (EIBS) at a time point that precedes the development of adenomas as well as any other currently available markers of colon cancer. Although it has been previously established that later-stage lesions (e.g. at the adenoma-carcinoma stage) have increased blood supply, ours were the first data to show such early aberrations of blood supply in early predysplastic stages of colon carcinogenesis. Therefore, optically detectable EIBS may potentially be used for diagnosis of previously undetectable stages of colonic neoplasia and may provide further insights into the pathophysiology of the earliest stages of colon carcinogenesis.

Original language	English (US)
Title of host publication	Biomedical Topical Meeting, BIOMED 2004
Publisher	Optica Publishing Group (formerly OSA)
ISBN (Electronic)	1557527695
State	Published - 2004
Event	Biomedical Topical Meeting, BIOMED 2004 - Miami Beach, United States Duration: Apr 14 2004 → Apr 17 2004

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Electronic)	2162-2701

Conference

Conference	Biomedical Topical Meeting, BIOMED 2004
Country/Territory	United States
City	Miami Beach
Period	4/14/04 → 4/17/04

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@inproceedings{fffae1fef97d4182a93c3109ee8d5122,

title = "Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis",

abstract = "We used polarization spectroscopy to investigated changes in subepithelial blood supply in the initial stages of colon carcinogenesis. We observed, for the first time, a profound early increase in subepithelial blood supply (EIBS) at a time point that precedes the development of adenomas as well as any other currently available markers of colon cancer. Although it has been previously established that later-stage lesions (e.g. at the adenoma-carcinoma stage) have increased blood supply, ours were the first data to show such early aberrations of blood supply in early predysplastic stages of colon carcinogenesis. Therefore, optically detectable EIBS may potentially be used for diagnosis of previously undetectable stages of colonic neoplasia and may provide further insights into the pathophysiology of the earliest stages of colon carcinogenesis.",

author = "Young Kim and Yang Liu and Ramesh Wali and Hemant Roy and Michael Goldberg and Vladimir Turzhitsky and Vadim Backman",

note = "Publisher Copyright: {\textcopyright} 2003 Optical Society of America; Biomedical Topical Meeting, BIOMED 2004 ; Conference date: 14-04-2004 Through 17-04-2004",

year = "2004",

language = "English (US)",

series = "Optics InfoBase Conference Papers",

publisher = "Optica Publishing Group (formerly OSA)",

booktitle = "Biomedical Topical Meeting, BIOMED 2004",

}

Kim, Y, Liu, Y, Wali, R, Roy, H, Goldberg, M, Turzhitsky, V & Backman, V 2004, Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis. in Biomedical Topical Meeting, BIOMED 2004., FG3, Optics InfoBase Conference Papers, Optica Publishing Group (formerly OSA), Biomedical Topical Meeting, BIOMED 2004, Miami Beach, United States, 4/14/04.

Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis. / Kim, Young; Liu, Yang; Wali, Ramesh et al.
Biomedical Topical Meeting, BIOMED 2004. Optica Publishing Group (formerly OSA), 2004. FG3 (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis

AU - Kim, Young

AU - Liu, Yang

AU - Wali, Ramesh

AU - Roy, Hemant

AU - Goldberg, Michael

AU - Turzhitsky, Vladimir

AU - Backman, Vadim

PY - 2004

Y1 - 2004

N2 - We used polarization spectroscopy to investigated changes in subepithelial blood supply in the initial stages of colon carcinogenesis. We observed, for the first time, a profound early increase in subepithelial blood supply (EIBS) at a time point that precedes the development of adenomas as well as any other currently available markers of colon cancer. Although it has been previously established that later-stage lesions (e.g. at the adenoma-carcinoma stage) have increased blood supply, ours were the first data to show such early aberrations of blood supply in early predysplastic stages of colon carcinogenesis. Therefore, optically detectable EIBS may potentially be used for diagnosis of previously undetectable stages of colonic neoplasia and may provide further insights into the pathophysiology of the earliest stages of colon carcinogenesis.

AB - We used polarization spectroscopy to investigated changes in subepithelial blood supply in the initial stages of colon carcinogenesis. We observed, for the first time, a profound early increase in subepithelial blood supply (EIBS) at a time point that precedes the development of adenomas as well as any other currently available markers of colon cancer. Although it has been previously established that later-stage lesions (e.g. at the adenoma-carcinoma stage) have increased blood supply, ours were the first data to show such early aberrations of blood supply in early predysplastic stages of colon carcinogenesis. Therefore, optically detectable EIBS may potentially be used for diagnosis of previously undetectable stages of colonic neoplasia and may provide further insights into the pathophysiology of the earliest stages of colon carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=85134613551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85134613551&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85134613551

T3 - Optics InfoBase Conference Papers

BT - Biomedical Topical Meeting, BIOMED 2004

PB - Optica Publishing Group (formerly OSA)

T2 - Biomedical Topical Meeting, BIOMED 2004

Y2 - 14 April 2004 through 17 April 2004

ER -

Polarization Spectroscopy of Early Increase in Blood Supply in Predysplastic Stages of Colon Carcinogenesis

Abstract

Publication series

Conference

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this