TY - JOUR
T1 - Polarized enhanced backscattering spectroscopy for characterization of biological tissues at subdiffusion length scales
AU - Radosevich, Andrew J.
AU - Rogers, Jeremy D.
AU - Turzhitsky, Vladimir
AU - Mutyal, Nikhil N.
AU - Yi, Ji
AU - Roy, Hemant K.
AU - Backman, Vadim
N1 - Funding Information:
Manuscript received September 1, 2011; revised October 20, 2011; accepted October 20, 2011. Date of publication October 27, 2011; date of current version July 6, 2012. This work was supported by the National Institute of Health under Grant RO1CA128641 and Grant RO1EB003682. The work of A. J. Radosevich was supported by the National Science Foundation Graduate Research Fellowship under Grant DGE-0824162.
PY - 2012
Y1 - 2012
N2 - Since the early 1980s, the enhanced backscattering (EBS) phenomenon has been well-studied in a large variety of nonbiological materials. Yet, until recently, the use of conventional EBS for the characterization of biological tissue has been fairly limited. In this study, we detail the unique ability of EBS to provide spectroscopic, polarimetric, and depth-resolved characterization of biological tissue using a simple backscattering instrument. We first explain the experimental and numerical procedures used to accurately measure and model the full azimuthal EBS peak shape in biological tissue. Next, we explore the peak shape and height dependencies for different polarization channels and spatial coherence of illumination. We then illustrate the extraordinary sensitivity of EBS to the shape of the scattering phase function using suspensions of latex microspheres. Finally, we apply EBS to biological tissue samples in order to measure optical properties and observe the spatial length scales at which backscattering is altered in early colon carcinogenesis.
AB - Since the early 1980s, the enhanced backscattering (EBS) phenomenon has been well-studied in a large variety of nonbiological materials. Yet, until recently, the use of conventional EBS for the characterization of biological tissue has been fairly limited. In this study, we detail the unique ability of EBS to provide spectroscopic, polarimetric, and depth-resolved characterization of biological tissue using a simple backscattering instrument. We first explain the experimental and numerical procedures used to accurately measure and model the full azimuthal EBS peak shape in biological tissue. Next, we explore the peak shape and height dependencies for different polarization channels and spatial coherence of illumination. We then illustrate the extraordinary sensitivity of EBS to the shape of the scattering phase function using suspensions of latex microspheres. Finally, we apply EBS to biological tissue samples in order to measure optical properties and observe the spatial length scales at which backscattering is altered in early colon carcinogenesis.
KW - Backscattering spectroscopy
KW - cancer detection
KW - enhanced backscattering (EBS)
KW - polarized light Monte Carlo
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U2 - 10.1109/JSTQE.2011.2173659
DO - 10.1109/JSTQE.2011.2173659
M3 - Article
C2 - 24163574
AN - SCOPUS:84863427174
SN - 1077-260X
VL - 18
SP - 1313
EP - 1325
JO - IEEE Journal of Selected Topics in Quantum Electronics
JF - IEEE Journal of Selected Topics in Quantum Electronics
IS - 4
M1 - 6062378
ER -
