Polarized light propagation through tissue and tissue phantoms

Vanitha Sankaran*, Jay Walsh, Duncan J. Maitland

*Corresponding author for this work

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

We show that standard tissue phantoms can be used to mimic the intensity and polarization properties of tissue. Polarized light propagation through biologic tissue is typically studied using tissue phantoms consisting of dilute aqueous suspensions of microspheres. The dilute phantoms can empirically match tissue polarization and intensity properties. One discrepancy between the dilute phantoms and tissue exist: common tissue phantoms, such as dilute Intralipid and dilute 1-μm-diameter polystyrene microsphere suspensions, depolarize linearly polarized light more quickly than circularly polarized light. In dense tissue, however, where scatterers are often located in close proximity to one another, circularly polarized light is depolarized similar to or more quickly than linearly polarized light. We also demonstrate that polarized light propagates differently in dilute versus densely packed microsphere suspensions, which may account for the differences seen between polarized light propagation in common dilute tissue phantoms versus dense biologic tissue.

Original languageEnglish (US)
Pages (from-to)178-186
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3915
StatePublished - Jan 1 2000
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications IV - San Jose, CA, USA
Duration: Jan 24 2000Jan 26 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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