Polycatechol Nanoparticle MRI Contrast Agents

Yiwen Li; Yuran Huang; Zhao Wang; Fabio Carniato; Yijun Xie; Joseph P. Patterson; Matthew P. Thompson; Christopher M. Andolina; Treffly B. Ditri; Jill E. Millstone; Joshua S. Figueroa; Jeffrey D. Rinehart; Miriam Scadeng; Mauro Botta; Nathan C. Gianneschi

doi:10.1002/smll.201502754

Polycatechol Nanoparticle MRI Contrast Agents

Yiwen Li, Yuran Huang, Zhao Wang, Fabio Carniato, Yijun Xie, Joseph P. Patterson, Matthew P. Thompson, Christopher M. Andolina, Treffly B. Ditri, Jill E. Millstone, Joshua S. Figueroa, Jeffrey D. Rinehart, Miriam Scadeng, Mauro Botta, Nathan C. Gianneschi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Amphiphilic triblock copolymers containing Fe^III-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T ₁-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.

Original language	English (US)
Pages (from-to)	668-677
Number of pages	10
Journal	Small
Volume	12
Issue number	5
DOIs	https://doi.org/10.1002/smll.201502754
State	Published - Feb 3 2016

Keywords

contrast agents relaxivity
melanin
micelles
polycatechols

ASJC Scopus subject areas

General Chemistry
Engineering (miscellaneous)
Biotechnology
General Materials Science
Biomaterials

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title = "Polycatechol Nanoparticle MRI Contrast Agents",

abstract = "Amphiphilic triblock copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T 1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.",

keywords = "contrast agents relaxivity, melanin, micelles, polycatechols",

author = "Yiwen Li and Yuran Huang and Zhao Wang and Fabio Carniato and Yijun Xie and Patterson, {Joseph P.} and Thompson, {Matthew P.} and Andolina, {Christopher M.} and Ditri, {Treffly B.} and Millstone, {Jill E.} and Figueroa, {Joshua S.} and Rinehart, {Jeffrey D.} and Miriam Scadeng and Mauro Botta and Gianneschi, {Nathan C.}",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2016",

month = feb,

day = "3",

doi = "10.1002/smll.201502754",

language = "English (US)",

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T1 - Polycatechol Nanoparticle MRI Contrast Agents

AU - Li, Yiwen

AU - Huang, Yuran

AU - Wang, Zhao

AU - Carniato, Fabio

AU - Xie, Yijun

AU - Patterson, Joseph P.

AU - Thompson, Matthew P.

AU - Andolina, Christopher M.

AU - Ditri, Treffly B.

AU - Millstone, Jill E.

AU - Figueroa, Joshua S.

AU - Rinehart, Jeffrey D.

AU - Scadeng, Miriam

AU - Botta, Mauro

AU - Gianneschi, Nathan C.

PY - 2016/2/3

Y1 - 2016/2/3

N2 - Amphiphilic triblock copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T 1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.

AB - Amphiphilic triblock copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T 1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.

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KW - melanin

KW - micelles

KW - polycatechols

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Polycatechol Nanoparticle MRI Contrast Agents

Abstract

Keywords

ASJC Scopus subject areas

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