Polycatechol Nanoparticle MRI Contrast Agents

Yiwen Li; Yuran Huang; Zhao Wang; Fabio Carniato; Yijun Xie; Joseph P. Patterson; Matthew P. Thompson; Christopher M. Andolina; Treffly B. Ditri; Jill E. Millstone; Joshua S. Figueroa; Jeffrey D. Rinehart; Miriam Scadeng; Mauro Botta; Nathan C. Gianneschi

doi:10.1002/smll.201502754

Polycatechol Nanoparticle MRI Contrast Agents

Yiwen Li, Yuran Huang, Zhao Wang, Fabio Carniato, Yijun Xie, Joseph P. Patterson, Matthew P. Thompson, Christopher M. Andolina, Treffly B. Ditri, Jill E. Millstone, Joshua S. Figueroa, Jeffrey D. Rinehart, Miriam Scadeng, Mauro Botta, Nathan C. Gianneschi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Amphiphilic triblock copolymers containing Fe^III-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T ₁-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.

Original language	English (US)
Pages (from-to)	668-677
Number of pages	10
Journal	Small
Volume	12
Issue number	5
DOIs	https://doi.org/10.1002/smll.201502754
State	Published - Feb 3 2016

Keywords

contrast agents relaxivity
melanin
micelles
polycatechols

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

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Li, Yiwen ; Huang, Yuran ; Wang, Zhao ; Carniato, Fabio ; Xie, Yijun ; Patterson, Joseph P. ; Thompson, Matthew P. ; Andolina, Christopher M. ; Ditri, Treffly B. ; Millstone, Jill E. ; Figueroa, Joshua S. ; Rinehart, Jeffrey D. ; Scadeng, Miriam ; Botta, Mauro ; Gianneschi, Nathan C. / Polycatechol Nanoparticle MRI Contrast Agents. In: Small. 2016 ; Vol. 12, No. 5. pp. 668-677.

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abstract = "Amphiphilic triblock copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T 1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.",

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Polycatechol Nanoparticle MRI Contrast Agents. / Li, Yiwen; Huang, Yuran; Wang, Zhao; Carniato, Fabio; Xie, Yijun; Patterson, Joseph P.; Thompson, Matthew P.; Andolina, Christopher M.; Ditri, Treffly B.; Millstone, Jill E.; Figueroa, Joshua S.; Rinehart, Jeffrey D.; Scadeng, Miriam; Botta, Mauro; Gianneschi, Nathan C.

In: Small, Vol. 12, No. 5, 03.02.2016, p. 668-677.

Research output: Contribution to journal › Article › peer-review

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AU - Rinehart, Jeffrey D.

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