Polycomb-mediated repression during terminal differentiation: What don't you want to be when you grow up?

Melissa L. Conerly, Kyle L. MacQuarrie, Abraham P. Fong, Zizhen Yao, Stephen J. Tapscott

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.

Original languageEnglish (US)
Pages (from-to)997-1003
Number of pages7
JournalGenes and Development
Volume25
Issue number10
DOIs
StatePublished - May 15 2011
Externally publishedYes

Keywords

  • Ezh2
  • Muscle growth
  • Muscle regeneration
  • Polycomb
  • Satellite cells

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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