Polycystic ovary syndrome: Syndrome XX?

Susan Sam, Andrea Dunaif*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

228 Scopus citations

Abstract

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic and reproductive disorder. It is associated with substantial defects in insulin action and secretion that confer a markedly increased risk for type 2 diabetes mellitus. Insulin resistance modifies reproductive function both by the direct actions of insulin on steroidogenesis and by disruption of insulin signaling pathways in the central nervous system. These insights have led to a new therapy for PCOS with insulin-sensitizing agents. Hyperandrogenemia and insulin resistance cluster in PCOS families, consistent with a genetic susceptibility to these abnormalities. There is evidence for both linkage and association of the hyperandrogenemia phenotype with an allele of a marker locus on chromosome 19, in the region of the gene encoding the insulin receptor.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume14
Issue number8
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Polycystic ovary syndrome: Syndrome XX?'. Together they form a unique fingerprint.

Cite this