Polymer biocompatibility-effect on hybridoma growth and metabolism

William M. Miller*, Andy A. Lin, Charles R. Wilke, Harvey W. Blanch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Hybridoma concentrations were reduced in shake flask and continuous culture by medical-grade PVC and polyurethane samples. Cell viability was unaffected and nutrient uptake rates were increased. No inhibition was observed for silicone, C-Flex or Teflon samples. The inhibition by PVC could be reduced by conditioning the sample with complete medium. The reduction in final cell yield and growth rate may result from extraction of one or more growth factors from the medium.

Original languageEnglish (US)
Pages (from-to)463-468
Number of pages6
JournalBiotechnology Letters
Volume8
Issue number7
DOIs
StatePublished - Jul 1 1986

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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